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Peptic Ulcer Disease

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Geriatric Gastroenterology

Abstract

Peptic ulcer disease and complications of peptic ulcer disease are common in the geriatric population. We discuss the main causes of ulcer disease, their diagnosis, treatment, complications, and prevention. This chapter deals with the pathophysiology, diagnosis, manifestations, and therapy of peptic ulcers with special emphasis on the diagnosis and management of ulcers and ulcer disease related to Helicobacter pylori, nonsteroidal anti-inflammatory drug use, and stress ulcers. We provide detailed advice regarding the mechanistic and therapeutic role of acid suppression medication for the treatment of peptic ulcer disease and prevention of related complications, in particular proton pump inhibitors and H. pylori diagnosis and therapy. There is also an in depth discussion of ulcer complications of obstruction, perforation, and upper gastrointestinal bleeding, with a comprehensive overview of the risk factors and medical and endoscopic treatment options for the most common ulcer complication of hemorrhage. The chapter provides readers with both a historical and current perspective on peptic ulcer disease to help guide therapy and clinical decision-making.

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Acknowledgments

Dr. Graham is supported in part by the Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service grant DK56338 which funds the Texas Medical Center Digestive Diseases Center. Dr. Graham is a consultant for RedHill Biopharma regarding novel H. pylori therapies and has received research support for culture of H. pylori and is the PI of an international study of the use of antimycobacterial therapy for Crohn’s disease. He is also a consultant for BioGaia in relation to probiotic therapy for H. pylori infection and for Takeda in relation to H. pylori therapies.

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  1. Each of the authors have been involved equally in study design, data acquisition, analysis, interpretation, and drafting the chapter. All have read and approved the final manuscript. Each meets the criteria for authorship established by the International Committee of Medical Journal Editors and verifies the validity of the results reported.

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  1. Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, TX, USA

    David Y. Graham & Natalia Khalaf

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  1. David Y. Graham
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Correspondence to David Y. Graham .

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  1. Saint Peter's Healthcare System, New Brunswick, NJ, USA

    C. S. Pitchumoni

  2. Albert Einstein College of Medicine, Montefiore Medical Center, Wakefield Campus, Bronx, NY, USA

    T.S. Dharmarajan

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Graham, D.Y., Khalaf, N. (2019). Peptic Ulcer Disease. In: Pitchumoni, C., Dharmarajan, T. (eds) Geriatric Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-90761-1_63-1

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