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Vaccination against Marek's disease: Immunizing effect of purified turkey herpes virus and cellular membranes from infected cells

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Abstract

One-day-old chickens susceptible to Marek's disease were vaccinated with experimental vaccines prepared from purified turkey herpes virus (HVT), inactivated HVT preparations or a membrane fraction isolated from HTV-infected chicken embryo fibroblasts, respectively. Purified HVT was found to be as effective in immunization against Marek's disease as cell-associated virus. The specific mortality of chickens twice vaccinated with cellular membranes from HVT-infected cells was reduced by 94%. These membranes also carried virus-specific antigens as shown by immunodiffusion tests.

From the vaccination and serologic findings one may conclude that the immunologic prevention of Marek's disease by vaccination with the HVT is mediated by antibodies against viral envelope and virus-specific membrane antigens.

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Authors and Affiliations

  1. Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen

    O. -R. Kaaden, B. Dietzschold & S. UeberschÄr

  2. Institut für Pathologie der TierÄrztlichen Hochschule Hannover, Deutschland

    S. UeberschÄr

Authors
  1. O. -R. Kaaden
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  2. B. Dietzschold
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  3. S. UeberschÄr
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Kaaden, O.R., Dietzschold, B. & UeberschÄr, S. Vaccination against Marek's disease: Immunizing effect of purified turkey herpes virus and cellular membranes from infected cells. Med Microbiol Immunol 159, 261–269 (1974). https://doi.org/10.1007/BF02123735

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  • DOI: https://doi.org/10.1007/BF02123735

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