Abstract
The effect of rifampicin on transplantable tumor growth and antitumor immunity was studied. The growth of transplantable lung sarcoma was significantly enhanced in mice when rifampicin was given for 7 days or longer. Also, the antitumor effects of preimmunization of the animals with killed tumor cells were abrogated by this antibiotic.
In vitro studies showed that spleen cells from tumor-bearing animals expressed significantly lower specific cytotoxicity toward syngeneic tumor cells, when the animals had been previously treated with rifampicin. Also, natural killer activity in healthy animals was diminished in mice receiving the antibiotic.
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References
Banck G, Forsgren A (1979) Antibiotics and suppression of lymphocyte function in vitro. Antimicrob Agents Chemother 16:554–560
Bassi L, Berardino L, Arioli V, Silvestri LG, Cherie Ligniere EL (1973) Conditions for immunosuppression by rifampicin. J Infect Dis 128:736–744
Becker S, Kiessling R, Lee N, Klein G (1978) Modulation of sensitivity of natural killer cell lysis after in vitro explantation of mouse lymphoma. J Nat Cancer Inst 61:1495–1498
Dajani BM, Kasik JE, Thompson JS (1973) Effect of rifampicin on the immune response in guinea pig. Antimicrob Agents Chemother 3:451–455
Finch R (1980) Immunomodulating effects of antimicrobial agents. J Antimicrob Chemother 6:691–699
Forsgren A, Schmeling D (1977) Effect of antibiotics on chemotaxis of human leukocytes. Antimicrob Agents Chemother 11:580–584
Grassi GG, Pozzi E (1972) Effect of rifampicin on delayed hypersensitivity reactions. J Infect Dis 126:542–544
Hanna N, Burton RC (1981) Definite evidence that natural killer cells inhibit experimental tumor metastasis in vivo. J Immunol 127:1754–1758
Hill RP, Bush RS (1969) A lung colony assay to determine the radiosensitivity of the cells of a solid tumor. Int J Radiat Biol 15:435–444
Hochmann PS, Cudkowicz G (1979) Suppression of natural cytotoxicity by spleen cells of hydrocortisone treated mice. J Immunol 123:968–976
Nilsson BS (1971) Rifampicin: an immunosuppressant? Lancet II:374
Ojo E, Haller O, Wigzell H (1978) Corynebacterium parvum induced peritoneal exudate cells with rapid cytolytic activity against tumour cells are non-phagocytic cells with characteristics of natural killer cells. Scand J Immunol 8:215–222
Richards V (1980) Cancer immunology — an overview. Prog Exp Tumor Res 25:1–60
Ruben FL, Winkelstein A., Fotiadis JG (1974) Immunological responsivness of tuberculosis patients receiving rifampicin. Antimicrob Agents Chemother 5:383–387
Serrou B (1974) Rifampicin and immunosuppression. Lancet II:172
Serrou B, Solassol C, Joyeux H, Pujol H, Romieu C (1972) Immunosuppressive effect of rifampicin. Transplantation 14:654–655
Weissman IL (1980) Tumor immunolgy, T cell maturation and T cell neoplasia. Prog Exp Tumor Res 25:193–218
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Roszkowski, W., Lipinska, R., Roszkowski, K. et al. Rifampicin-induced suppression of antitumor immunity. Med Microbiol Immunol 172, 197–205 (1984). https://doi.org/10.1007/BF02123714
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DOI: https://doi.org/10.1007/BF02123714