Summary
Pregnant women were treated with infusions of acetylsalicylic acid (ASA). The plasma concentrations of total salicylate or those of ASA and salicylic acid (SA) were determined. The ASA steady state was reached after 2 h of infusion whereas 3 days seemed necessary to reach the steady state of SA.
In a further study during the late phase of cervical dilatation (12 min – 2 h before birth) healthy pregnant women were given 1 g ASA as a single i.v. bolus injection. The resulting plasma levels of ASA and SA in the mothers during delivery, the plasma concentrations in umbilical cord blood and in blood obtained from the newborn several hours after birth were measured. With increasing time the SA concentrations in the umbilical cord blood plasma approached those of the mothers. On the other hand, the umbilical cord blood concentrations of ASA did not approach the maternal concentrations, probably because of the ASA esterase activity at the placental barrier. The plasma concentrations in the newborn indicated that the newborn is able to degrade ASA and to excrete SA. However, the velocities are lower than the respective velocities in adults.
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References
Levy G (1965) Pharmocokinetics of Salicylate elimination in man. J Pharm Sci 54: 959–967
Levy G, Tsuchiya T (1972) Salicylate accumulation kinetics in man. N Engl J Med 287: 430–432
Nöschel H, Bonow A, Möller R, Estel C, Müller B (1972) Plazentapassage von Natriumcalizylate. Zentralbl Gynäkol 94: 437–442
O'Dea K, Pütter J, Hoffmeister F (1975) Antinociceptive action and plasmalevels of acetylsalicylic acid in the dog. Arzneim Forsch 25: 801–806
Pütter J (1971) Pharmakokinetik der Acetylsalizylsäure. Ther Ber 43: 205–212
Pütter J, O'Dea K, Hoffmeister F (1976) Bestimmung der Pharmakonzentration an Acetylsalizylsäure und Salizylsäure bei Hunden. Pharmaberichte Bayer 22: 41–44
Pütter J (1976) Übersicht über die Pharmakokinetik der Acetylsalizylsäure. Med Welt 27: 1362–1365
Pütter J (1979) Die Bioverfügbarkeit, erläutert am Beispiel der Acetylsalizylsäure. Dtsch Apoth Ztg 119: 758–802
Vinazzer H, Pütter J, Loew D (1975) Influence of intravenously administered acetylsalicylic acid and platelet functions. Haemostasis 4: 12–22
Voß H, v., Göbel U, Petrick C, Pütter J (1978) Pharmacokinetic investigations in adult humans after parenteral administration of the lysine salt of acetylsalicylic acid. Klin Wochenschr 56: 1119–1123
Wolff F, Meier U, Bolte A (1979) Untersuchungen zum Pathomechanismus schwerer kardiopulmonaler Komplikationen unter tokolytischer Behandlung mit β-adrenergen Substanzen und Betamethason. Z Geburtshilfe Perinatol 183: 343–347
Wolff F, Berg R, Bolte A (1981) Klinische Untersuchungen zur wehenhemmenden Wirkung der Acetylsalizylsäure (ASS) und ihrer Nebenwirkungen. Geburtshilfe Frauenheilkd 41: 96–100
Wolff F, Berg R, Meier U (1977) Untersuchungen über die Pharmakokinetik präpartual intravenös verabreichter Acetylsalizylsäure. In: Schmidt E, Dudenhausen JW, Saling E (Hrsg) Perinatale Medizin, Bd VII. Thieme, Stuttgart, S 142–143
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Wolff, F., Berg, R., Bolte, A. et al. Perinatal pharmacokinetics of acetylsalicylic acid. Arch. Gynecol. 233, 15–22 (1982). https://doi.org/10.1007/BF02110674
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DOI: https://doi.org/10.1007/BF02110674