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P-glycoprotein and cell volume-activated chloride channels

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Abstract

The multidrug resistance P-glycoprotein (P-gp) is an active drug transporter which can expel hydrophobic compounds from cells. Expression of P-gp has many effects on cells and tissues and the physiological function, or functions, of P-gp are still unclear. Recently, expression of P-gp has been associated with altered activity of chloride channels which play a role in regulating cell volume of response to osmotic shock or nutrient uptake. The nature and physiological role of this association has been a subject of some debate. In this article, mechanisms by which P-gp might influence cell volume-activated chloride currents is discussed, and the potential physiological role of this regulation considered.

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  1. Nuffield Department of Clinical Biochemistry, and Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK

    Christopher F. Higgins

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  1. Christopher F. Higgins
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Higgins, C.F. P-glycoprotein and cell volume-activated chloride channels. J Bioenerg Biomembr 27, 63–70 (1995). https://doi.org/10.1007/BF02110332

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