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Cell Membrane Transport Mechanisms: Ion Channels and Electrical Properties of Cell Membranes

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Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 227))

Abstract

Cellular life strongly depends on the membrane ability to precisely control exchange of solutes between the internal and external (environmental) compartments. This barrier regulates which types of solutes can enter and leave the cell. Transmembrane transport involves complex mechanisms responsible for passive and active carriage of ions and small- and medium-size molecules. Transport mechanisms existing in the biological membranes highly determine proper cellular functions and contribute to drug transport. The present chapter deals with features and electrical properties of the cell membrane and addresses the questions how the cell membrane accomplishes transport functions and how transmembrane transport can be affected. Since dysfunctions of plasma membrane transporters very often are the cause of human diseases, we also report how specific transport mechanisms can be modulated or inhibited in order to enhance the therapeutic effect.

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Acknowledgments

This work was supported by the Polish National Science Centre project SONATA BIS 6 - SONB.A040.17.001 (2016/22/E/NZ5/00671).

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Authors and Affiliations

  1. Department of Medical Biochemistry, Wroclaw Medical University, Chalubińskiego 10, 50-367, Wrocław, Poland

    Julita Kulbacka, Anna Choromańska & Jolanta Saczko

  2. Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wrocław, Poland

    Joanna Rossowska

  3. Department of Dental Prosthetics, Division of Dental Materials, Wrocław Medical University, Krakowska 26, 50-425, Wrocław, Poland

    Joanna Weżgowiec

  4. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, 205 Route de Narbonne, BP 64182, F-31077, Toulouse, France

    Marie-Pierre Rols

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  1. Julita Kulbacka
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  4. Joanna Weżgowiec
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Correspondence to Julita Kulbacka .

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  1. Wroclaw Medical University, Dept. of Medical Biochemistry, Wroclaw, Poland

    Julita Kulbacka

  2. Vytautas Magnus University, Bio. Res. Group/Bio Dept., Kaunas, Lithuania

    Saulius Satkauskas

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Kulbacka, J., Choromańska, A., Rossowska, J., Weżgowiec, J., Saczko, J., Rols, MP. (2017). Cell Membrane Transport Mechanisms: Ion Channels and Electrical Properties of Cell Membranes. In: Kulbacka, J., Satkauskas, S. (eds) Transport Across Natural and Modified Biological Membranes and its Implications in Physiology and Therapy. Advances in Anatomy, Embryology and Cell Biology, vol 227. Springer, Cham. https://doi.org/10.1007/978-3-319-56895-9_3

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