Abstract
Gap junction channels are an integral part of the conduction or propagation of an action potential from cell to cell. Gap junctions have rather unique gating and permeability properties which permit the movement of molecules from cell to cell. These molecules may not be directly linked to action potentials but can alter nonjunctional processes within cells, which in turn can affect conduction velocity. The data described in this review reveal that, for the majority of excitable cells, there are two limiting factors, with respect to gap junctions, that affect the conduction/propagation of action potentials. These are (1) the total number of channels and (2) the selective permeability of the channels. Interestingly, voltage dependence and the time course of voltage inactivation (kinetics) are not rate limiting steps under normal physiological conditions for any of the connexins studied so far. Only specialized rectifying electrical synapses utilize strong voltage dependence and rapid kinetics to permit or deny the continued propagation of an action potential.
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References
Barr, L., Dewey, M. M., and Berger, W. (1965).J. Gen. Physiol. 48, 797–823.
Barr, L., Berger, W., and Dewey, M. M. (1968).J. Gen. Physiol. 51, 346–368.
Beeler, G. W., and Reuter, H. (1977).J. Physiol. 268, 177–210.
Benz, R. (1986). InIon Channel Reconstitution (Miller, C., ed.), Plenum Press, New York, pp. 553–573.
Bennett, M. V. L., and Verselis, V. K. (1992).Sem. Cell Biol. 3, 29–47.
Bennett, M. V. L., Zheng, X., and Sogin, M. L. (1995).Prog. Cell Res. 4, 3–8.
Berger, W., and Barr, L. (1969).J Appl. Physiol. 26, 378–382.
Beyer, E. C. (1993).Int. Rev. Cytol. 137, 1–37.
Blatz, A. L., and Magleby, K. L. (1984).J Gen. Physiol. 84, 1–23.
Brink, P. R., (1991).J. Cardiovas. Electrophysiol. 2, 360–366.
Brink, P. R., and Dewey, M. M. (1978).J. Gen. Physiol. 72, 67–86.
Brink, P. R., and Dewey, M. M. (1980).Nature 285, 101–102.
Brink, P. R., and Fan, S. F. (1989).Biophys. J. 56, 579–593.
Brink, P. R., and Ramanan, S. V. (1985).Biophys. J. 48, 299–309.
Brink, P. R., Ramanan, S. V., and Christ, G. (1996).Am. J. Physiol. Cell, in press.
Bukauskas, F., Elfgand, C., Willecke, K., and Weingart, R. (1995).Pflugers Arch. 429, 870–872.
Bullock, T. H. (1945).J. Neurophysiol. 8, 55–71.
Burt, J. M. (1991). InBiophysics of Gap Junction Channels (Perrachia, C., ed.), CRC Press, Boca Raton, Florida, pp. 75–96.
Cole, W. C., Picone, J. B., and Sperelakis, N. (1988).Biophys. J. 53, 809–818.
Dermietzel, R., and Spray, D. C. (1993).Trends Neurosci. 16, 186–92.
Eccles, J.,et al. (1933).J. Physiol. 77, 23–25.
Fursphan, E. J., and Potter, D. D. (1957).Nature 180, 342–343.
Fursphan, E. J., and Potter, D. D. (1959).J. Physiol. 145, 289–325.
Fushiki, S., and Kinoshita, C. (1995).Progr. Cell Res. 4, 239–244.
Goodenough, D. A. (1975).Cold Spring Harbor Symp. Quant. Biol. 40, 37–48.
Jaslove, S. W., and Brink, P. R. (1986).Nature 323, 63–65.
Jaslove, S. W., and Brink, P. R. (1987). InCell-to-Cell Communication (DeMello, C., ed.), Plenum Press, New York.
Little, T. L., Xia, J., and Duling, B. R. (1995).Circ. Res. 76, 498–504.
Lowenstein, W. R. (1981).Physiol. Rev. 61, 829–913.
Makowski, L., Casper, D., Philips, W., Baker, T.,et al. (1984).Biophys. J. 45, 208–218.
Margiotta, J. F., and Walcott, B. (1983).Nature 305, 52–55.
Mirro, J., Bailey, J. D., and Watnabe, A. M. (1980). InThe Slow Inward Current and Cardiac Arrythmias (Zipes, D. P., Bailey, J. C., and Eiharrar, V., eds.), Martinus Nijhoff Publishers, pp. 111–127.
Moreno, A. P., Fishman, G. I., Beyer, E. C., and Spray, D. C. (1995).Prog. Cell Res. 4, 405–408.
Neyton, J., and Trautmann, A. (1985).Nature 317, 331–335.
Robinson, S. R., Hampson, E. C. G. M., Munro, M. N., and Vaney, D. I. (1993).Science 262, 1072–1074.
Rudiusli, A., and Weingart, R. (1991). InBiophysics of Gap Junction Channels (Perrachia, C., ed.), CRC Press, Boca Raton, Florida, pp. 43–56.
Spray, D. C., and Bennett, M. V. L. (1985).Ann. Rev. Physiol. 47, 281–303.
Tsien, R., and Weingart, R. (1976).J. Physiol. 260, 117–141.
Veenstra, R. D., Wang, Z., Beyer, E. C., Ramanan, S. V., and Brink, P. R. (1994a).Biophys. J. 66, 1915–1928.
Veenstra, R. D., Wang, Z., Beyer, E. C., and Brink, P. R. (1994b).Circ. Res. 268, 706–712.
Veenstra, R. D., Wang, H. Z., Beblo, D. A., Cliton, M. G., Harris, A. L., Beyer, E. C., and Brink, P. R. (1995).Cir. Res. 77, 1156–1165.
Verselis, V. K., Bargiello, T. A., Rubin, J. B., and Bennett, M. V. L. (1994).Nature 368, 348–351.
Wang, H.-Z., Li, J., Lemanski, L. F., and Veenstra, R. D. (1992).Biophys. J. 63, 139–151.
Weidmann, S. (1966).J. Physiol. 187, 322–342.
Weingart, R. (1986).J. Physiol. 370, 267–284.
White, T. W., Paul, D., Goodenough, D. A., and Bruzzone, R. (1995).Mol. Biol. Cell 6, 459–470.
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Brink, P.R., Cronin, K. & Ramanan, S.V. Gap junctions in excitable cells. J Bioenerg Biomembr 28, 351–358 (1996). https://doi.org/10.1007/BF02110111
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DOI: https://doi.org/10.1007/BF02110111