Summary
The relationship between the deficiency of CpG dinucleotides and the coding-noncoding segments of DNA has been examined. Analysis of five human α-like globin DNA sequences and five human β-like globin DNA sequences reveal that there is no apparent difference between protein coding and non-coding protions of DNA. Rather CpG deficiency appears to be a property of long contiguous segments of DNA consisting of several genes and their intergenic regions. Thus we propose that CpG deficiency is not involved with translation or transcription but rather is related to chromosomal constraints.
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Lennon, G.G., Fraser, N.W. CpG frequency in large DNA segments. J Mol Evol 19, 286–288 (1983). https://doi.org/10.1007/BF02099976
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DOI: https://doi.org/10.1007/BF02099976