Summary
Natural DNA sequences were recently found to contain distinct nearest neighbor patterns. Hetero-dinucleotides were demonstrated to appear consistently more (less) than their mirror-image counterparts. This paper shows that this assymmetric behavior does not stem from the coding requirements of the DNA. It also shows some codon patterns in prokaryotic and eukaryotic genomes which came up in the course of this work.
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Nussinov, R. The universal dinucleotide asymmetry rules in DNA and the amino acid codon choice. J Mol Evol 17, 237–244 (1981). https://doi.org/10.1007/BF01732761
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DOI: https://doi.org/10.1007/BF01732761