Abstract
Reduced peritoneal clearances of creatinine and urate were demonstrated repeatedly in a patient with scleroderma and a patient with diabetes mellitus. Urea clearances were not significantly different from usual values. The findings suggest decreased peritoneal membrane permeability and/or area (if urea clearance is flow limited). Clearances increased to usual values with intraperitoneal isoproterenol in the patient with diabetes. There was no effect of isoproterenol in the patient with scleroderma.
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Brown, S. T., Ahearn, D. J., Nolph, K. D.: Reduced peritoneal clearances in scleroderma increased by intraperitoneal isoproterenol.Ann. Int. Med. 78, 891 (1973).
Henderson, L. W., Nolph, K. D.: Altered permeability of the peritoneal membrane after using hypertonic peritoneal dialysis fluid.J. Clin. Invest. 48, 992 (1969).
Henry, R. J., Chiamori, N.: On the direct Nesslerization of ammonia formed by urease treatment of blood serum, and urine.Am. J. Clin. Pathol. 29, 277 (1958).
Henry, R. J., Sobel, C., Kim, J.: A modified carbonate-phosphotungstate method for the the determination of uric acid and comparison with the spectrophotometric uricase method.Am. J. Clin. Pathol. 28, 152 (1957).
Karnovsky, M. J.: The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.J. Cell Biol. 35, 213 (1967).
Nolph, K. D., Stolz, M. L., Maher, J. F.: Altered peritoneal permeability in patients with systemic vasculitis.Ann. Int. Med. 75, 753 (1971).
Nolph, K. D., Whitcomb, M. E., Schrier, R. W.: Mechanisms for inefficient peritoneal dialysis in acute renal failure associated with heat stress and exercise.Ann. Int. Med. 71, 317 (1969).
Owen, J. A., Iggo, B., Scandrett, F. J., Stewart, C. P.: The determination of creatinine in plasma or serum, and in urine; a critical examination.Biochem. J. 58, 426 (1954).
Romeo, S. G., Whalen, R. E., Tindall, J. P.: Intra-arterial administration of reserpine.Arch. Int. Med. 125, 825 (1970).
Willerson, J. T., Thompson, R. H., Hookman, P., Herdt, J., Decker, J. L.: Reserpine in Raynaud's disease and phenomenon. Short-term response to intra-arterial injection.Ann. Int. Med. 72, 17 (1970).
Winkelmann, R. K., Kierland, R. R., Perry, H. O., Muller, S. A., Sams, W. M. Jr.: Management of scleroderma.Mayo Clin. Proc. 46, 128 (1971).
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Nolph, K.D., Miller, L., B. S. et al. Peritoneal clearances in scleroderma and diabetes mellitus: Effects of intraperitoneal isoproterenol. International Urology and Nephrology 8, 161–169 (1976). https://doi.org/10.1007/BF02082213
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DOI: https://doi.org/10.1007/BF02082213