Abstract
Growth ofLactobacillus acidophilus was inhibited in the presence of deoxyadenosine-5′-monophosphate (dAMP). The other purine deoxyribonucleotides and -sides were only weak inhibitors, and pyrimidine deoxyribotides and -sides were inactive. dAMP did not act as an inhibitor if thymine, thymidine, or 5-methyldeoxycytidine-5′-monophosphate was present in the medium. The inhibition by dAMP was counteracted by increasing concentrations of deoxyuridine, deoxyuridine-5′-monophosphate and, to some extent, adenosine-5′-monophosphate. The effect of these substances was proportional to their concentration and competitive in character. The results support the assumption that dAMP inhibits the synthesis of thymine. Mutants ofL. acidophilus resistant to inhibition by dAMP were found.
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Koukalová, B., Soška, J. & Reich, J. Inhibition of thymine synthesis inLactobacillus acidophilus R-26 by deoxyadenosine-5′-monophosphate. Antonie van Leeuwenhoek 33, 17–24 (1967). https://doi.org/10.1007/BF02045529
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DOI: https://doi.org/10.1007/BF02045529