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Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis

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Summary

No significant differences were found in plasma concentrations and urinary excretion of prostaglandin E2 (PGE2), 6-keto-prostaglandin-F1α (6-keto-F PGF1α) and thromboxane B2 (T−xB2), between rheumatoid arthritis patients and controls. However, urinary excretion of PGEe and 6-keto-PGF1α tended to be greater and plasma levels of TxB2 lower in rheumatoid arthritis. Plasma concentrations and urinary excretion showed no marked circadian variation, although night or morning values were slightly lower. Plasma and urine prostaglandins do not correlate with clinical symptomatology in rheumatoid arthritis.

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Authors and Affiliations

  1. Department of Clinical Sciences, University of Tampere, Box 607, SF-33101, Tampere 10, Finland

    O. Laitinen

  2. Department of Biomedical Sciences, University of Tampere, Box 607, SF-33101, Tampere 10, Finland

    E. Seppalä & H. Vapaatalo

  3. Rheumatism Foundation Hospital, SF-18120, Heinola 12, Finland

    M. Nissilä

Authors
  1. O. Laitinen
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  2. E. Seppalä
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  3. M. Nissilä
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  4. H. Vapaatalo
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Laitinen, O., Seppalä, E., Nissilä, M. et al. Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. Clin Rheumatol 2, 401–406 (1983). https://doi.org/10.1007/BF02041562

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  • DOI: https://doi.org/10.1007/BF02041562

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