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Gonyauline: A novel endogenous substance shortening the period of the circadian clock of a unicellular alga

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Summary

The circadian clock in the unicellular algaGonyaulax polyedra is accelerated by a substance in extracts from the cells themselves. The extracts have been fractionated using the circadian rhythm of bioluminescence as bioassay. The active substance, termed gonyauline, has been isolated and characterized as a novel low molecular weight cyclopropanecarboxylic acid (S-methyl-cis-2-(methylthio) cyclopropanecarboxylic acid). Synthetic gonyauline has a similar shortening effect on the period of the circadian clock.

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Author notes

  1. T. Roenneberg

    Present address: Medizinische Psychologie, Universität München, Goethestrasse 31, D-8000, München, Germany

  2. H. Nakamura

    Present address: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, Japan

Authors and Affiliations

  1. Department of Cellular and Developmental Biology, Harvard University, 02138, Cambridge, Massachusetts, USA

    T. Roenneberg, L. D. Cranmer III, K. Ryan & J. W. Hastings

  2. Department of Chemistry, Harvard University, 02138, Cambridge, Massachusetts, USA

    H. Nakamura & Y. Kishi

Authors
  1. T. Roenneberg
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  2. H. Nakamura
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  3. L. D. Cranmer III
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  4. K. Ryan
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  5. Y. Kishi
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  6. J. W. Hastings
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Roenneberg, T., Nakamura, H., Cranmer, L.D. et al. Gonyauline: A novel endogenous substance shortening the period of the circadian clock of a unicellular alga. Experientia 47, 103–106 (1991). https://doi.org/10.1007/BF02041268

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  • DOI: https://doi.org/10.1007/BF02041268

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