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Malformin C, an algicidal peptide from marine fungus Aspergillus species

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Abstract

A natural compound with the algicidal effect was isolated from the culture medium of Aspergillus sp. SCSIOW2 and was identified as malformin C, which was based on the data of 1H-NMR, 13C-NMR, and ESI-MS. Malformin C exhibited dose-dependent algicidal activities against two strains of noxious red tide algae, Akashiwo sanguinea and Chattonella marina. The activity against A. sanguinea was stronger than that against C. marina (the algicidal activity of 58 and 36% at 50 μM treatment for 2 h, respectively). Morphology changes including perforation, plasmolysis, and fragmentation of algal cells were observed. Malformin C induced a significant increase in ROS level, caused the damage of SOD activity, and led to the massive generation of MDA contents in algae cells. To our knowledge, this is the first report of the cyclic peptide described as an algicidal compound against HABs.

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Acknowledgements

This work was supported by the Science and Technology Innovation Commission of Shenzhen (Grant No. JCYJ20170817141403781, JCYJ20180305123659726, JCYJ20190808114415068), National Key Research and Development Project 2018YFA0902504 and 2019YFC0312501. We thank the Instumental Analysis Center of Shenzhen University for the NMR measurement.

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Authors and Affiliations

  1. Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Key Laboratory of Marine Bioresource and Eco-environmental Science, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518071, PR China

    Xiaofan Li, Zhenyao Xia, Liwen Lai, Tuchan Li, Jiahui Wu & Liyan Wang

  2. Shenzhen Institute for drug control, Shenzhen Key Laboratory of Drug Quality Standard Research, Shenzhen, 518057, PR China

    Bing Wang & Jue Wang

  3. Instumental Analysis Center of Shenzhen University, Shenzhen, 518071, PR China

    Linhai Jiang

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  1. Xiaofan Li
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Correspondence to Liyan Wang.

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Li, X., Xia, Z., Wang, B. et al. Malformin C, an algicidal peptide from marine fungus Aspergillus species. Ecotoxicology 30, 996–1003 (2021). https://doi.org/10.1007/s10646-021-02389-3

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