Abstract
The growing importance of specific activity is reviewed. It concerns especially surface phenomena, toxicity, labelling of radiopharmaceuticals, isotope exchange, enzymatic and pharmacological ligand-receptor reactions. The present state of evaluating the specific activity has been analyzed. Introduction of the coefficient DCF (deviation from true carrier free state) is proposed as a possibility for universal declaration of the specific activity.
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J. PROKOP, K. SVOBODA, F. BUDSKÝ, Proc. IV. Intern. Symp. Radiopharmaceutical Chemistry, Jülich, 1982, p. 291; J. Label. Comp. Radiopharm., 19 (1982) 1563.
J. MARHOLD, Review of Industrial Toxicology (in Czech), SZN-publishing-house, Prague, 1964, p. 143.
O. RIEDL, V. VONDRÁČEK, Clinical Toxicology (in Czech), Avicenum, Prague, 1980, p. 471.
V. HUŠÁK, J. VLČEK, Intern. J. Appl. Radiation Isotopes, 30 (1979) 165.
S. C. SRIVASTAVA, G. MEINKEN, T. D. SMITH, P. RICHARDS, Intern. J. Appl. Radiation Isotopes, 28 (1977) 83.
F. HOUDEK, I. OBRUSNÍK, K. SVOBODA, Radiochem. Radioanal. Lett., 39 (1979) 343.
K. SVOBODA, V. HUŠÁK, J. VLČEK, F. HOUDEK, J. Labell. Comp. Radiopharmaceuticals, 16 (1979) 122.
S. MATTSSON J. Radioanal. Chem., 45 (1978) 341.
E. DEUTSCH, W. R. HEINEMAN, J. P. ZODDA, T. W. GILBERT, C. C. WILLIAMS, Intern. J. Appl. Radiation Isotopes, 33 (1982) 843.
G. BERGER, D. COMAR, J. SASTRE, C. PRENAUT, C. KELLERSOHN, Proc. 3rd World Congress on Nuclear Medicine and Biology, Paris, 1982, p. 2143.
J. TÖLGYESSY, T. BRAUN, M. KYRŠ, Isotope Dilution Analysis, Pergamon, Oxford, 1972.
M. KYRŠ, J. TÖLGYESSY, G. N. BILIMOVIČ, J. KRTIL, L. KUČA, New Methods of Radioanalytical Chemistry (in Russian), Energoizdat, Moscow, 1982.
G. FRIEDLENDER, J. KENNEDY, Introduction to Radiochemistry (Russian version), Moscow, 1952, p. 290.
I. P. ALIMARIN, K. F. SVOBODA, Atomnaya Energiya, 5 (1958) 73.
K. SVOBODA, Coll. Czech. Chem. Commun., 28 (1963) 1338.
K. SVOBODA, Coll. Czech. Chem. Commun., 29 (1964) 1513.
K. SVOBODA, Nature, 198 (1963) 986.
K. SVOBODA, Isotopenpraxis, 8 (1972) 351.
K. SVOBODA, Rept. Nucl. Res. Inst., Řež, ÚJV-2712-Ch, 1971.
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Svoboda, K. Significance of specific activity and a possible universal unit for its definition. Journal of Radioanalytical and Nuclear Chemistry, Articles 88, 13–29 (1985). https://doi.org/10.1007/BF02037300
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DOI: https://doi.org/10.1007/BF02037300