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Differential effects of opiates on the incorporation of [14C] thiamine in the central nervous system of the rat

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Summary

Opiate agonist (morphine), pure antagonist (naloxone), mixed agonist-antagonist (nalorphine) and analgesically inactive enantiomorph (dextrorphan) produced differential stereoselective effects on the incorporation of [14C] thiamine in the central nervous system of the rats. The possible role of thiamine in opiate effects and its implications are discussed.

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Literatur

  1. A. von Muralt, Ann. N. Y. Acad. Sci.98, 499 (1962).

    Article  CAS  Google Scholar 

  2. Y. Itokawa and J. R. Cooper, Biochim. Biophys. Acta196, 274 (1970).

    Article  CAS  PubMed  Google Scholar 

  3. I. G. Leder, Thiamine, Biosynthesis and Function, in: Metabolic Pathways 7, 57, 3rd ed. Ed. D. M. Greenberg. Academic Press, New York 1975.

    Google Scholar 

  4. H. McIlwain and H. S. Bachelard, in: Biochemistry of the Central Nervous System, p. 275, 280. Williams and Wilkins Co. Baltimore, Maryland 1971.

    Google Scholar 

  5. A. Herz, K. Albus, J. Metys, P. Schubert and H. Teschemacher, Neuropharmacology9, 539 (1970).

    Article  CAS  PubMed  Google Scholar 

  6. D. J. Mayer, T. L. Wolfle, H. Akil, B. Carder and J. C. Liebeskind, Science174, 1351 (1971).

    Article  CAS  PubMed  Google Scholar 

  7. P. K. Dey and W. Feldberg, J. Physiol., Lond.248, 40P (1975).

  8. S. K. Sharma and J. H. Quastel, Biochem. J.94, 790 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. A. L. Misra, C. L. Mitchell and L. A. Woods, Nature, Lond.232, 48 (1971).

    Article  CAS  PubMed  Google Scholar 

  10. A. L. Misra and S. J. Mulé, Nature, Lond.238, 155 (1972).

    Article  CAS  PubMed  Google Scholar 

  11. A. L. Misra, S. J. Mulé, R. Bloch and N. L. Vadlamani, J. Pharmac. exp. Ther.185, 287 (1973).

    CAS  Google Scholar 

  12. A. L. Misra, N. L. Vadlamani, R. Bloch and S. J. Mulé, Res. Comm. Chem. Path. Pharmac.7, 1 (1974).

    CAS  Google Scholar 

  13. A. L. Misra, R. B. Pontani and S. J. Mulé, Xenobiotica4, 17 (1974).

    Article  CAS  PubMed  Google Scholar 

  14. L. Angelucchi, Nature, Lond.181, 967 (1958).

    Article  Google Scholar 

  15. R. Dufait, Arch. int. Pharmacodyn.66, 274 (1941).

    CAS  Google Scholar 

  16. R. L. Swank and H. H. Jasper, Arch. Neurol. Psychiat.47, 821 (1942).

    Article  CAS  Google Scholar 

  17. O. G. Fitzhugh, J. Pharmac. exp. Ther.67, 423 (1939).

    CAS  Google Scholar 

  18. H. L. Cardenas and D. H. Ross, J. Neurochem.24, 487 (1975).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Testing and Research Laboratory, New York State Office of Drug Abuse Services, 80, Hanson Place, 11217, Brooklyn, N. Y., USA

    A. L. Misra, N. L. Vadlamani & R. B. Pontani

Authors
  1. A. L. Misra
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  2. N. L. Vadlamani
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  3. R. B. Pontani
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Additional information

To whom reprint requests should be addressed. The authors thank Dr. S. J. Mulé, Assistant Commissioner and Director, ODAS Testing and Research Laboratory, for his kind interest and support and Mrs J. Vardy, Mr A. Kramer and Mr V. Aschettino for assistance.

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Misra, A.L., Vadlamani, N.L. & Pontani, R.B. Differential effects of opiates on the incorporation of [14C] thiamine in the central nervous system of the rat. Experientia 33, 372–374 (1977). https://doi.org/10.1007/BF02002834

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