Skip to main content
SpringerLink
Log in

Histamine release induced by glucose (mannose)-specific lectins isolated from Brazilian beans. Comparison with concanavalin A

  • Allergy and Histamine
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

The histamine releasing properties of glucose (mannose)-specific lectins isolated from Brazilian beans was examined. TheCanavalia brasiliensis, Dioclea rostrata, andDioclea virgata lectins induced histamine release in rat peritoneal mast cells similar to concanavalin A. Less potency and efficacy was observed forCanavalia maritima, Dioclea guianensis, andDioclea violacea while very low activities were seen for the lectins fromDioclea grandiflora, Canavalia bonariensis, andCratylia floribunda.

The histamine releasing effect was quenched by higher doses ofD. virgata lectin similar to what was reported for concanavalin A. This effect was abrogated by increasing the concentration of calcium in the incubating medium. As these above proteins have sites that bind calcium, higher doses of the lectins might withdraw the calcium which is essential for the mast cell secretion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. E. Leiner, N. Sharon and I. J. Goldstein,The Lectins: properties, functions, and applications in biology and Medicine. p. 600, Academic Press, London 1986.

    Google Scholar 

  2. H. Lis and N. Sharon,The biochemistry of plant lectins. Ann. Rev. Biochem.42, 541–574 (1973).

    Article  PubMed  Google Scholar 

  3. N. Sharon and H. Lis,Legumes lectins — A large family of homologous proteins. FASEB J.4, 3198–3208 (1990).

    PubMed  Google Scholar 

  4. R. Keller,Concanavalin A, a model “antigen” for the in vitro detection of cell-bound reaginic antibody rat. Clin. Exp. Immunol.13, 139–147 (1973).

    PubMed  Google Scholar 

  5. A. M. Magro and H. Bennich,Concanavalin A induced histamine release from human basophils in vitro. Immunology33, 51–58 (1977).

    PubMed  Google Scholar 

  6. K. Sugiyama, J. Sasaki and H. Yamasaki,Potentiation by phosphatidylserine of calcium-dependent histamine release from rat mast cells induced by concanavalin A. Jap. J. Pharmacol.25, 485–487 (1975).

    PubMed  Google Scholar 

  7. T. J. Sullivan, W. C. Greene and C. W. Parker,Concanavalin A-induced histamine release from normal rat mast cells. J. Immunol.115, 278–282 (1975).

    PubMed  Google Scholar 

  8. P. A. Siraganian and R. P. Siraganian,Basophil activation by concanavalin A: characteristics of the reaction. J. Immunol.112, 2117–2125 (1974).

    PubMed  Google Scholar 

  9. D. Lagunoff, T. W. Martin and G. Read,Agents that release histamine from mast cells. Ann. Rev. Pharmacol. Toxicol.23, 331–351 (1983).

    Article  Google Scholar 

  10. R. A. Moreira, A. C. H. Barros, J. C. Steward and A. Pusztai,Isolation and characterization of a lectin from the seeds of Dioclea grandifloraMart. Planta158, 63–69 (1983).

    Article  Google Scholar 

  11. R. A. Moreira and B. S. Cavada,Lectin from Canavalia brasiliensis(Mart). Isolation, characterization and behavior during germination. Biologia Plantarum (Praha)26, 113–120 (1984).

    Google Scholar 

  12. J. T. A. Oliveira, B. S. Cavada and R. A. Moreira,Isolation and partial characterization of a lectin from Cratylia floribundaMart. seeds. Revista Brasileira de Botânica14, 61–66 (1991).

    Google Scholar 

  13. I. M. Vasconcelos, B. S. Cavada, R. A. Moreira and J. T. A. Oliveira,Purification and partial characterization of a lectin from the seeds of Dioclea guianensis. J. Food Biochem.1511, 137–154 (1991).

    Google Scholar 

  14. R. A. Moreira, I. L. Ainouz, J. T. A. Oliveira and B. S. Cavada,Plant lectins, chemical and biological aspects. Memorias do instituto Oswaldo Cruz86, 211–218 (1991).

    PubMed  Google Scholar 

  15. J. L. Wang, B. A. Cunningham and G. Edelman,Unusual fragments in the subunit structure of concanavalin A. Proc. Natl. Acad. Sci.68, 1130–1134 (1971).

    PubMed  Google Scholar 

  16. M. Barral-Netto, S. B. Santos, A. Barral, L. I. M. Moreira, C. F. Santos, RA, Moreira RA, J. T. A. Oliveira and B. S. Cavada,Human Lymphocyte stimulation by legume lectins from the Dicleaetribe. Immunol. Invest.21, 297–303 (1992).

    PubMed  Google Scholar 

  17. J. Wyczolkwska, A. Prouvost and R. Rydzynski,Lectin-induced histamine release from various populations of hamster mast cells. Agents and Actions23, 217–220 (1988).

    Google Scholar 

  18. M. S. Lima, M. C. Oliveira, R. A. Moreira and A. Prouvost-Danon,Metabolic energy dependent exocytosis of mouse mast cells by lectin of Dioclea grandiflora(Mart.). Biochem. Pharmacol.34, 4169–4170 (1985).

    Article  PubMed  Google Scholar 

  19. F. L. Pearce,On the heterogeneity of mast cells. Pharmacology32, 61–71 (1986).

    PubMed  Google Scholar 

  20. W. A. Hook, S. F. Dougherty and J. J. Oppenheim,Release of histamine from hamster mast cells by concanavalin and phytohemagglutinin. Infect. Immun.9, 903–908 (1974).

    PubMed  Google Scholar 

  21. Y. Morita, Y. Matsumoto, T. Miyamoto and Y. A. Horiuchi,A clinical study of concanavalin A-induced histamine release utilizing a single isotopic enzymatic assay of histamine. Ann. Allergy40, 47–50 (1978).

    PubMed  Google Scholar 

  22. A. J. Shores and J. L. Mongar,Modulation of histamine secretion from concanavalin A-activated rat mast cells by phosphatidyl serine, calcium, cAMP pH and metabolic inhibitors. Agents and Actions10, 131–137 (1980).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Institute of Biosciences, Unesp, 18618-000, Botucatu, SP, Brazil

    J. C. Gomes & R. Rossi Ferreira

  2. Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE, Brazil

    B. Sousa Cavada, R. Azevedo Moreira & J. T. A. Oliveira

Authors
  1. J. C. Gomes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Rossi Ferreira
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Sousa Cavada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Azevedo Moreira
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. T. A. Oliveira
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gomes, J.C., Ferreira, R.R., Cavada, B.S. et al. Histamine release induced by glucose (mannose)-specific lectins isolated from Brazilian beans. Comparison with concanavalin A. Agents and Actions 41, 132–135 (1994). https://doi.org/10.1007/BF02001905

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02001905

Key words

Search

Navigation