Abstract
Adjuvant arthritis has been studied in young copper-deficient rats and a very strong inhibition of the disease following 60 days of deficient diet (0.4 ppm of copper) was found. No difference in lung prostaglandin synthesis and in rat stomach strip and colon reactivity to exogenous prostaglandins was noticed between controls and copper-deficient animals.
These results are briefly discussed.
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References
M.M. Wintrobe, G.E. Cartwright andC.J. Gubler,Studies on the Function and Metabolism of Copper, J. Nutr.50, 395 (1953).
D.S. Karabelas,Copper Metabolism in the Adjuvant Induced Arthritic Rat, Univ. Microfilms. Ann Arbor, Mich., Order No. 72-31,092. From Diss. Abstr. Int. B 1972-33(6), 2776 (1972).
M.W. Whitehouse,Ambivalent, Role of Copper in Inflammatory Disorders, Agents and Actions6, 201 (1976).
P.R. Scudder, D. Al-Timini, W. McMurray, A.G. White, B.C. Zoob andT.L. Dormandy,Serum Copper and Related Variables in Rheumatoid Arthritis, Ann. Rheum. Dis.37, 67 (1978).
P.R. Scudder, W. McMurray, A.G. White andT.L. Dormandy,Synovial Fluid Copper and Related Variables in Rheumatoid and Degenerative Arthritis, Ann. Rheum. Dis.37, 71 (1978).
J.M. McCord,Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase, Science185, 529 (1974).
Y. Ōyanagui,Participation of Superoxide Anions at the Prostaglandin Phase of Carrageenan Foot-Oedema, Biochem. Pharmacol.25, 1465 (1976).
T. Richardson,Salicylates, Copper Complexes, Free Radicals and Arthritis, J. Pharm. Pharmac.28, 666 (1976).
J.R.J. Sorenson,Copper Chelates as Possible Active Forms of the Antiarthritic Agents, J Med. Chem.19, 135 (1976).
K.D. Rainsford andM.W. Whitehouse,Concerning the Merits of Copper Aspirin as a Potential Anti-Inflammatory Drug, J. Pharm. Pharmac.28, 83 (1976).
M.W. Whitehouse andW.R. Walker,Copper and Inflammation, Agents and Actions8, 85 (1978).
W.R. Walker andR. Reeves,Ternary Copper(II) Complexes Containing Salicylate and Nitrogenous Chelates such as Histamine, in:Proc. Symposium ‘Aspirin and Related Drugs: Their Actions and Uses (Eds. K.D. Rainsford, K. Brune and M.W. Whitehouse: Birkhäuser Verlag, Basel, 1976), p. 109.
W.R. Walker andD.M. Keats,An Investigation of the Therapeutic Value of the ‘Copper Bracelet’. Dermal Assimilation of Copper in Arthritic/Rheumatoid Conditions, Agents and Actions,6, 454 (1976).
C.A. Owen, Jr. andJ.B. Hazelrig,Copper Deficiency and Copper Toxicity in the Rat. Am. J. Physiol215, 334 (1968).
Analytical Methods for Atomic Absorption Spectrophotometry, BC-5, March 1971 (Perkin-Elmer, publisher).
R. Milanino, E. Passarella andG.P. Velo,Adjuvant Arthritis in Copper Deficient Rats, Abstracts of the ‘Joint Meeting of German and Italian Pharmacologists’ (Venezia, 1977), p. 366.
R.E. Lee andW.E.M. Lands,Cofactors in the Biosynthesis of Prostaglandins F 1α and F 2α . Biochem. Biophys. Acta260, 203 (1972).
I.S. Maddox,The Role of Copper in Prostaglandin Synthesis. Biochem. Biophys. Acta306, 74 (1973).
G.P. Velo, C.J. Dunn, J.P. Giroud, J. Timsit andD.A. Willoughby,Distribution of Prostaglandins in Inflammatory Exudate, J. Pathol.111, 149 (1973).
J.P. Giroud, G.P. Velo andD.A. Willoughby,The Role of Prostaglandins and Cyclic Nucleotides in Inflammation, in:Prostaglandins and Thromboxanes (Eds. F. Berti, B. Samuelsson and G.P. Velo; Plenum Press, New York, 1977), p. 323.
L. Treagan,Metals and the Immune Response. A Review, Res. Comm. Chem. Path. Pharmacol.12, 189 (1975).
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Milanino, R., Passarella, E. & Velo, G.P. Adjuvant Arthritis in young copper-deficient rats. Agents and Actions 8, 623–628 (1978). https://doi.org/10.1007/BF01998892
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DOI: https://doi.org/10.1007/BF01998892