Skip to main content
SpringerLink
Log in

The influence of superoxide scavenging compound CTC 23 on type II collagen-induced arthritis in mice

  • Inflammation and Immunomodulation
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

The anti-arthritic activity of the superoxide scavenging compound CTC 23 was tested in murine type II collagen-induced arthritis (CIA). CTC 23 demonstrated a dose-dependant prevention of the onset of CIA, with a significant reduction of disease incidence in mice receiving prophylactic administration of CTC 23 from 2.5–5 mg/kg/day. CTC 23 also delayed the development of the anti-collagen immune response, causing a significant decrease in antibody levels 14 days after immunization. CTC 23 reduced the arthritis score and number of involved limbs in mice with established CIA. The results suggest that CTC 23 acts as a disease modifying anti-arthritic compound to prevent the progression of the experimental arthritis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. A. Roberts,Free radicals immunoglobulins and complement as mediators of inflammation. Baillieres Clinical Rheumatology2, 211–232 (1988).

    Google Scholar 

  2. B. Haliwell, J. R. Hoult and D. R. Blake,Oxidants, inflammation, and anti-inflammatory drugs. Faseb Journal2, 2867–2873 (1988).

    PubMed  Google Scholar 

  3. A. Vaille, G. Jadot and E. Elizagaray,Anti-inflammatory activity of various superoxide dismutases on polyarthritis in the Lewis rat. Biochemical Pharmacology39, 247–255 (1990).

    PubMed  Google Scholar 

  4. W. E. Linhart, G. Steinwender, W. Weybora, S. Zadravec and H. Esterbauer,Influence of superoxide dismutase on staphylococcal arthritis — A histological and biochemical investigation using an experimental animal model. Agents Actions29, 259–265 (1990).

    PubMed  Google Scholar 

  5. D. Dejica, G. Szegli, A. Herold, N. Bucurenci and E. Mazilu,Local treatment with Epurox (superoxide dismutase and catalase of human origin) in the chronic inflammatory and degenerative rheumatism. Archives Roumaines De Pathologie Experimentale Et De Microbiologie45, 299–310 (1986).

    Google Scholar 

  6. K. Lund-Oleson and K. B. Menander-Huber,Orgotein: a new anti-inflammatory metalloprotein drug: preliminary evaluation of clinical efficacy and safety in degenerative joint disease. Curr Ther Res16, 706–717 (1974).

    PubMed  Google Scholar 

  7. K. B. Menander-Huber,Orgotein in the treatment of rheumatoid arthritis. Eur J Rheumatol Inflamm4, 201–211 (1981).

    PubMed  Google Scholar 

  8. U. S. Patent #4866054.

  9. G. Costa, G. Mestroni, G. Tauzder and L. Stefani,Organometallic derivatives of cobalt chelates of Bis(acetylacetone) ethylendiamine. J. Organometal. Chem.6, 181–187 (1966).

    Google Scholar 

  10. J. D. Crapo, J. M. McCord and I. Fridovich,Preparation and assay of superoxide dismutases. Methods in Enzymology53, 382–393 (1978).

    PubMed  Google Scholar 

  11. E. C. Dunkel, P. A. Geary, J. Brooks and D. Pavan-Langston,CTC 23 efficacy in vitro and on HSV-1-induced ocular epithelial and stromal disease in the rabbti.Anti-Viral Research, 1, 135 (1990).

    Google Scholar 

  12. D. Gershon, Z. Dori,Anti-inflammatory and anti-arthritic activity of metal compounds with superoxide scavenging ability. Technical Report, Chai-Tech Corp., Greenvale, NY 11548, (1986).

    Google Scholar 

  13. P. H. Wooley, H. S. Luthra, J. M. Stuart and C. S. David,Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. Journal of Experimental Medicine154, 688–700 (1981).

    PubMed  Google Scholar 

  14. J. S. Courtenay, M. J. Dallman, A. D. Dayan, A. Martin and B. Mosedale,Immunisation against heterologous type II collagen induces arthritis in mice. Nature283, 666–668 (1980).

    PubMed  Google Scholar 

  15. K. Phadke, R. L. Fouts, J. E. Parrish and L. D. Butler,Evaluation of the effects of various anti-arthritic durgs on type II collagen-induced mouse arthritis model. Immunopharmacology10, 51–60 (1985).

    PubMed  Google Scholar 

  16. G. W. Cannon, S. McCall, B. C. Cole, M. M. Griffiths, L. A. Radov and J. R. Ward,Effects of indomethacin, cyclosporin, cyclophosphamide, and placebo on collagen-induced arthritis of mice. Agents Actions29, 315–323 (1990).

    PubMed  Google Scholar 

  17. P. H. Wooley,Collagen-induced arthritis in the mouse. Methods in Enzymology162, 361–373 (1988).

    PubMed  Google Scholar 

  18. P. H. Wooley, J. R. Seibold, J. D. Whalen and J. M. Chapdelaine,Pristane-induced arthritis. The immunological and genetic features of an experimental murine model of autoimmune disease. Arthritis & Rheumatism32, 1022–1030 (1989).

    Google Scholar 

  19. J. M. Stuart, L. K. Myers, A. S., Townes and A. H. Kang,Effect of cyclophosphamide, hydrocortisone and levamisole on collagen-induced arthritis in rats. Arthritis & Rheumatism24, 790–794 (1981).

    Google Scholar 

  20. R. B. Gilbertsen,Effects of pentostatin (2′ deoxycoformycin), an inhibitor of adenosine deaminase, on type II collagen-induced arthritis in rats. Journal of Immunopharmacology7, 325–341 (1985).

    PubMed  Google Scholar 

  21. J. M. Stuart, M. A. Cremer, A. H. Kang and A. S. Townes,Collagen-induced arthritis in rats. Evaluation of early immunologic events. Arthritis & Rheumatism22, 1344–1351 (1979).

    Google Scholar 

  22. D. E. Trentham, A. S. Townes, A. H. Kang and J. R. David,Humoral and cellular sensitivity to collagen in type II collagen- induced arthritis in rats. Journal of Clinical Investigation61, 89–96 (1978).

    PubMed  Google Scholar 

  23. G. Jadot, A. M. Michelson and K. Puget,Anti-inflammatory activity of superoxide dismutases: studies on adjuvant induced polyarthritis in rats. Free Radical Research Communications2, 27–42 (1986).

    PubMed  Google Scholar 

  24. C. Beauchamp, R. B. Gilbertson, J. Rantone and D. P. Menapace, Fed. Proc.42, 6354 (1983) (Abstract)

    Google Scholar 

  25. M. Castell, J. J. Moreno, J. C. Oliva, J. Queralt and M. C. Castellote,Effect of indomethacin, benoxaprofen and superoxide dismutase on serum sulfhydryl levels in adjuvant Arthritis. Farmaco-Edizione Pratica42, 233-Edizione P (1987).

  26. B. A. Hart, J. M. Simons, S. Knaan-Shanzer, N. P. Bakker and R. P. Labadie,Antiarthritic activity of the newly developed neutrophil oxidative burst antagonist apocynin. Free Radical Biology & Medicine9, 127–131 (1990).

    Google Scholar 

  27. A. M. Badger, D. A. Schwartz, D. H. Picker, J. W. Dorman, F. C. Bradley, E. N. Cheeseman, M. J. DiMArtino, N. Hanna and C. K. Mirabelli,Antiarthritic and supressor cell inducing activity of azaspiranes: structure-function relationships of a novel class of immunodulatory agents. J. Med. Chem.33, 2963–2970 (1990).

    PubMed  Google Scholar 

  28. S. Goodman,Therapeutic effects of organic germanium. Medical Hypothesis26, 207–215 (1988).

    Google Scholar 

  29. H. Aso, F. Suzuki, T. Yamaguchi, T. Ebina and N. Ishida,Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, an organic germanium compound. Gan To Kagaku Ryoho9, 1976–1980 (1982).

    PubMed  Google Scholar 

  30. T. Kasama, K. Kobayashi, T. Fukushima, M. Tabata, I. Ohno, M. Negishi, H. Ide, T. Takahashi and Y. Niwa,Production of interleukin 1-like factor from human peripheral blood monocytes and polymorphonuclear leukocytes by superoxide anion: the role of interleukin 1 and reactive oxygen species in inflamed sites. Clinical Immunology & Immunopathology53, 439–448 (1989).

    Google Scholar 

  31. J. T. Hom, A. M. Bendele and D. G. Carlson,In vivo administration with IL-1 accelerates the development of collagen-induced arthritis in mice. J. Immunol.141, 834–841 (1988).

    PubMed  Google Scholar 

  32. L. M. Killar and C. J. Dunn,Interleukin-1 potentiates the development of collagen-induced arthritis in mice. Clinical Science76, 535–538 (1989).

    PubMed  Google Scholar 

  33. P. H. Wooley, N. D. Staite, J. D., Whalen, D. L. Chapman, A. E. Berger, D. G. Aspar and K. A. Richard,The effect of interleukin-1 receptor antagonist protein on type II collagen and antigen-induced arthritis in mice. Arthritis & Rheumatism33, S20 (1990) (Abstract)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Rheumatology, Departments of Internal Medicine and Immunology, Wayne State University Medical School, 48201, Detroit, MI, USA

    P. H. Wooley & J. D. Whalen

Authors
  1. P. H. Wooley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. D. Whalen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wooley, P.H., Whalen, J.D. The influence of superoxide scavenging compound CTC 23 on type II collagen-induced arthritis in mice. Agents and Actions 35, 273–279 (1992). https://doi.org/10.1007/BF01997511

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01997511

Keywords

Search

Navigation