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Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig

  • Pulmonary Diseases
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Abstract

The interactions between LPS-induced bronchial hyper-reactivity (BHR) and lung inflammation (LI) were investigated. LPS-induced LI was assessed with the augmented alveolo-capillary permeability (ACP) and with the increased migration of neutrophils into the broncho-alveolar lavage fluid. BHR was defined as the increase in the response to a standard dose of serotonin. Mepyramine and the PAF antagonist WEB 2170 blocked LPS-induced increase of ACP, whereas aspirin was inactive. By contrast, neither LPS-induced neutrophil attraction to airways, nor LPS-induced HBR were inhibited by these agents. Our results indicate that LPS-induced edema and BHR are dissociated.

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Authors and Affiliations

  1. Service de Médecine Interne, Centre d'Allergie, Hôpital Rothschild, 33 boulevard de Picpus, 75012, Paris, France

    D. Vincent & J. Dry

  2. Unité de Pharmacologie Cellulaire, Unité Associée Institut Pasteur/INSERM no285, 25 rue du Docteur Roux, 75015, Paris, France

    D. Vincent, J. Lefort, M. Bureau & B. B. Vargaftig

Authors
  1. D. Vincent
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  2. J. Lefort
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  3. M. Bureau
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  4. J. Dry
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  5. B. B. Vargaftig
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Vincent, D., Lefort, J., Bureau, M. et al. Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. Agents and Actions 34, 203–204 (1991). https://doi.org/10.1007/BF01993279

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  • DOI: https://doi.org/10.1007/BF01993279

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