Abstract
Several autacoids such as histamine and leukotrienes induce bronchoconstriction. Histamine is an important mediator of immediate allergic and inflammatory reactions. It causes bronchoconstriction by activating H1-receptors. Calcium ionophores induce the release of leukotrienes via the 5-lipoxygenase pathway. Leukotrienes are powerful bronchoconstrictors that appear to act on smooth muscles via specific receptors. In this method, drugs are tested for their capability of inhibiting bronchospasm induced by histamine or calcium ionophore. It is used to detect H1- and leukotriene receptor blocking properties of test compounds.
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Bruse, K.D. (2015). Effects of Drugs on Air Ways. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27728-3_23-1
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DOI: https://doi.org/10.1007/978-3-642-27728-3_23-1
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27728-3
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