Summary
After 3 weeks of continuous ethanol intoxication by inhalation, the maximal number and affinity of the α-and β-receptors of rat heart were unchanged. These data indicate that adrenergic receptor disturbances are not involved in the mechanism of chronic ethanol-induced triglyceride deposition in the heart.
Similar content being viewed by others
References
M. Victor, Post-grad. med. J.47, 68 (1970).
E.M. Sellers and H. Kalant, New Engl. J. Med.294, 757 (1976).
C.D. Marsden, T.M. Gilmette, R.G. Mc Allister, D.A.L. Owen and T.N. Miller, Acta endocr.57, 353 (1968).
D.H. Zilm, E.M. Sellers, S.M. Mac Leod and N.C. Degani, Ann. int. Med.83, 234 (1974).
E.M. Sellers, N.C. Degani, D.H. Zilm and S.M. Mac Leod, Lancet1, 94 (1976).
S.P. Banerjee, V.K. Sharma and J.M. Khanna, Nature276, 407 (1978).
B. Le Bourhis C.r. Soc. Biol.169, 898 (1975).
R.S. Williams and R.J. Lefkowitz, Circulation Res.43, 721 (1978).
Y. Giudicelli and R. Pecquery, Eur. J. Biochem.90, 413 (1978).
R. Pecquery, L. Malagrida and Y. Giudicelli, FEBS Lett.98, 241 (1979).
D. Scatchard, Ann. N.Y. Acad. Sci. USA51, 660 (1949).
L.T. Williams and R.J. Lefkowitz, in: Receptor Binding Studies in Adrenergic Pharmacology, p. 27. Raven Press, New York 1978.
J.M. Khanna, H. Kalant and G. Bustos, Can. J. Physiol. Pharmac.45, 777 (1967).
W.A. Hunt, T.K. Harden and R.G. Thurman, Drug Alcohol Depend.4, 327 (1979).
M. Karobath, J. Rogers and F.E. Bloom, Neuropharmacology19, 125 (1980).
D.R. Christian, G.S. Kilsheimer, G. Pettett, R. Paradise and J. Ashmore, in: Advances in Enzyme Regulation vol. 7, p. 71. Ed. G. Weber, Pergamon Press. Oxford 1969.
R. Nordmann, B. Le Bourhis, M. Clément, G. Jean and G. Aufrère, in: Proceeding 25th International Institute on the Prevention and Treatment of Alcoholism, p. 296. ICAA Publication, Lausanne 1979.
Author information
Authors and Affiliations
Additional information
Acknowledgments. This work was supported by grants from the Institut National de la Santé et de la Recherche Médicale. We wish to thank Mr M. Clément for skilled technical assistance in performing chronic ethanol inhalation treatments.
Rights and permissions
About this article
Cite this article
Sabourault, D., Bauché, F., Giudicelli, Y. et al. Alpha- and beta-adrenergic receptors in rat myocardium membranes after prolonged ethanol inhalation. Experientia 37, 227–229 (1981). https://doi.org/10.1007/BF01991624
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01991624