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Dantrolene and the effect of temperature on the spontaneous release of transmitter at the frog neuromuscular junction

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Summary

The characteristic effect of temperature on m.e.p.p. frequency at the amphibian neuromuscular junction is unaltered by the presence of Dantrolene (an agent that is believed to reduce the efflux of Ca2+ from intracellular stores) or by changes in [Ca2+]o. It is concluded that temperature affects the release system directly, with a transition temperature at about 16°C.

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Author notes

  1. S. J. Publicover

    Present address: Department of Zoology and Comparative Physiology, University of Birmingham, P. O. Box 363, B 15 2TT, Birmingham, (England)

Authors and Affiliations

  1. Department of Zoology, University of Liverpool, P. O. Box 147, L69 3BX, Liverpool, (England)

    S. J. Publicover & C. J. Duncan

Authors
  1. S. J. Publicover
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  2. C. J. Duncan
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Publicover, S.J., Duncan, C.J. Dantrolene and the effect of temperature on the spontaneous release of transmitter at the frog neuromuscular junction. Experientia 37, 859–860 (1981). https://doi.org/10.1007/BF01985680

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  • DOI: https://doi.org/10.1007/BF01985680

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