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Inhibitory effect of lysophosphatidylcholine on the histamine release from rat peritoneal mast cells

  • Mechanisms of Histamine Release
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Abstract

Histamine release from isolated rat peritoneal mast cells induced by compound 48/80 (0.5 μg/ml) or antigen-antibody reaction was inhibited by lysophosphatidylcholine in a dose-dependent fashion at concentrations up to 4 μM. Within the same range of concentration, lysophosphatidylcholine exhibited a membrane-stabilizing action on the model membrane systems decreasing the permeability of lipid bilayer and the fluidity of liposomal membrane in the liquid crystalline state. At concentrations higher than 8 μM, lysophosphatidylcholine damaged the cell membrane and subsequently histamine was released. It was assumed that lysophosphatidylcholine may act as an endogenous membrane stabilizer inhibiting histamine release in normal mast cells.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, 700, Okayama, Japan

    M. Mio, A. Ikeda, M. Akagi & K. Tasaka

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  1. M. Mio
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  2. A. Ikeda
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  3. M. Akagi
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  4. K. Tasaka
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Mio, M., Ikeda, A., Akagi, M. et al. Inhibitory effect of lysophosphatidylcholine on the histamine release from rat peritoneal mast cells. Agents and Actions 16, 113–117 (1985). https://doi.org/10.1007/BF01983115

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  • DOI: https://doi.org/10.1007/BF01983115

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