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Thermal analysis of amorphous phase in a pharmaceutical drug

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Abstract

Thermally Stimulated Current (TSC) spectroscopy and Differential Scanning Calorimetry (DSC) have been applied to the characterization of the microstructure of a pharmaceutical drug.

The dielectric relaxation spectrum shows two modes located in the temperature range of the glass transition. They have been attributed to the molecular mobility in the “true amorphous phase” and in the ≪rigid amorphous region≫.

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Authors and Affiliations

  1. Polymer Physic Laboratory, Paul Sabatier University, 31062, Toulouse Cédex

    N. Fagegaltier, A. Lamure & C. Lacabanne

  2. Sanofi Research, 34000, Montpellier

    A. Caron

  3. Sanofi Research, 31036, Toulouse Cédex, France

    H. Mifsud & M. Bauer

Authors
  1. N. Fagegaltier
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  2. A. Lamure
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  3. C. Lacabanne
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  4. A. Caron
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  5. H. Mifsud
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  6. M. Bauer
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Fagegaltier, N., Lamure, A., Lacabanne, C. et al. Thermal analysis of amorphous phase in a pharmaceutical drug. Journal of Thermal Analysis 48, 459–464 (1997). https://doi.org/10.1007/BF01979492

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  • DOI: https://doi.org/10.1007/BF01979492

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