Abstract
Tiopronin (50 mg/kg) andd-penicillamine (50 mg/kg) do not exhibit anti-inflammatory effects in classic animal models (carragenin oedema, granuloma cotton pellets) but suppress pertussis vaccine oedema, an immunological model, when given with a long-lasting dosing regime.
Tiopronin andd-penicillamine also fail to inhibit PG release by phagocytosing leucocytes when the concentrations used were in the same range as human blood levels (5–15 μg/ml).
Indomethacin (1, 3 and 5 mg/kg) instead significantly inhibits both thein vivo andin vitro models considered.
This may imply a different mode of action of both tiopronin andd-penicillamine from indomethacin. Tiopronin also possesses similar effects tod-penicillamine suggesting that their overall anti-rheumatic action may have common elements.
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Capasso, F. Some pharmacological properties of tiopronin. Agents and Actions 11, 741–745 (1981). https://doi.org/10.1007/BF01978799
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DOI: https://doi.org/10.1007/BF01978799