Abstract
The hypothesls that fallure of histamine (Hi)-mediated inter and intracellulary cell-cell communication may be involved in the control of cellular growth has been tested in leukaemia-bearing mice and fibrosarcoma-bearing rats.
In all examined tissues of mice bearing leukaemia L1210 cells and rats bearing methylcholanthrene fibrosarcoma histamine content was higher than in controls.
Tissues of fibrosarcoma-bearing rats more intensively metabolized14C-Hi and oxidative pathway was predominat. Histamine metabolic activity as well as histamine catabolic pathways do not differ in leukaemic mice as compared with the controls.
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Maśliński, C., Kierska, D., Sasiak, K. et al. Histamine and its catabolism in tumour-bearing rat and mouse. Agents and Actions 14, 497–500 (1984). https://doi.org/10.1007/BF01973858
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DOI: https://doi.org/10.1007/BF01973858