Skip to main content
SpringerLink
Log in

Dose-DNA adduct relationship for ethylene oxide

  • Letter to the Editor
  • Published:
Archives of Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bolt HM, Kappus H, Buchter A, Bolt W (1976) Disposition of [1, 2-14C] vinyl chloride in the rat. Arch Toxicol 35: 153–162

    Article  PubMed  Google Scholar 

  • Bolt HM, Peter H, Föst U (1988) Analysis of macromolecular ethylene oxide adducts. Int Arch Occup Environ Health 60: 141–144

    Article  PubMed  Google Scholar 

  • Brugnone F, Perbellini L, Faccini GB, Pasini F, Bartolucci GB, De Rosa E (1986) Ethylene oxide exposure. Biological monitoring by analysis of alveolar air and blood. Int Arch Occup Environ Health 58: 105–120

    Article  PubMed  Google Scholar 

  • Filser JG (1992) The closed chamber technique — uptake, endogenous production, excretion, and rates of metabolism of gases and vapours. ArchToxicol 66: 1–10

    Google Scholar 

  • Filser JG, Bolt HM (1984) Inhalation pharmacokinetics based on gas uptake studies VI: Comparative evaluation of ethylene oxide and butadiene monoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats. Arch Toxicol 55: 219–223

    Article  PubMed  Google Scholar 

  • Föst U, Marczynski B, Kasemann R, Peter H (1989) Determination of 7-(2-hydroxyethyl)guanine with gas chromatography/mass spectrometry as a parameter for genotoxicity of ethylene oxide. Arch Toxicol Suppl 13: 250–253

    Google Scholar 

  • Johanson G, Filser JG (1992) Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation. Arch Toxicol 66: 291–295

    PubMed  Google Scholar 

  • Lutz WK (1979) In vivo covalent binding of chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat Res 23: 283–295

    Google Scholar 

  • Potter D, Blair D, Watson WP, Wright AS (1989) The relationship between alkylation of haemoglobin and DNA in Fischer 344 rats exposed to [14C] ethylene oxide. Arch Toxicol Suppl 13: 254–257

    Google Scholar 

  • Walker VE, Fennell TR, Boucheron JA, Fedtke N, Ciroussel F, Swenberg JA (1990) Macromolecular adducts of ethylene oxide: a literature review and a time-course study on the formation of 7-(2-hydroxyethyl)guanine following exposures of rats by inhalation. Mutat Res 233: 151–164

    PubMed  Google Scholar 

  • Walker VE, Fennell TR, Upton PB, Skopek TR, Prevost V, Shuker DEG, Swenberg JA (1992) Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice. Cancer Res 52: 4328–4334

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Arbeitsphysiologie an der Universität Dortmund, Ardeystrasse 67, D-44139, Dortmund, Germany

    H. M. Bolt & M. Leutbecher

Authors
  1. H. M. Bolt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Leutbecher
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This is an abridged report of the research conducted. The full data are available from the authors on request.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bolt, H.M., Leutbecher, M. Dose-DNA adduct relationship for ethylene oxide. Arch Toxicol 67, 712–713 (1993). https://doi.org/10.1007/BF01973696

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01973696

Keywords

Search

Navigation