Abstract
Gas uptake studies were carried out to evaluate kinetic interactions between 1,3-butadiene and styrene in Sprague-Dawley rats. The animals were co-exposed by inhalation to a mixture of 1,3-butadiene between 20 and 6000 ppm (v/v) and styrene between 0 and 500 ppm. The data demonstrate that metabolism of 1,3-butadiene was partialy inhibited by styrene. The inhibition was competitive at atmospheric concentrations of styrene up to 90 ppm. Higher concentrations of styrene resulted in a small additional inhibition only. The apparent Michaelis-Menten constant for 1,3-butadiene, related to the average concentration in the organism of the animals, was Kmapp = 1.17±0.37 (Μmol/l of tissue) and the corresponding atmospheric concentration at steady state was 560 ppm. The inhibition constant of styrene was found to be Ki = 0.23±0.30 (Μmol/l of tissue). The maximal metabolic rate for 1,3-butadiene was 230±10 (Μ/kg/h).
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On leave from Central Research Institute of Chemistry, Hungarian Academy of Sciences, Budapest, Hungary
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Laib, R.J., Tucholski, M., Filser, J.G. et al. Pharmacokinetic interaction between 1,3-butadiene and styrene in Sprague-Dawley rats. Arch Toxicol 66, 310–314 (1992). https://doi.org/10.1007/BF01973624
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DOI: https://doi.org/10.1007/BF01973624