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The pharmacology of 2-(2-fluoro-4-biphenylyl)Propionic acid (Flurbiprofen) A potent non-steroidal anti-inflammatory drug

  • Histamine and Kinins Immunosuppression and Inflammation
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Abstract

Flurbiprofen is a potent, orally active, nonsteroidal anti-inflammatory drug in experimental animals. It is less toxic and more potent than indomethacin in certain types of acute and chronic inflammation in the rat. Like indomethacin, flurbiprofen has a prolonged duration of antiinflammatory action. It is effective in all in vitro assay systems used currently for the assessment of other nonsteroidal anti-inflammatory drugs. It is more potent than indomethacin in only one of these in vitro systems, red cell aggregation and sedimentation caused by the addition of dextran. Flurbiprofen may prove to be a useful adjunct for the treatment of various inflammatory diseases in man.

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References

  1. S.S. Adams andK.F. McCullough, Abstract # 33.2 of the VII European Rheumatology Congress, 1971 Brighton, England (1971).

  2. C.D. Brooks, F.R. Schmidt andJ. Biundo, Rheumatol. Phys. Med. Suppl. (Incorporating Annals of Physical Medicine), p. 48–63 (1970).

  3. I.M. Chalmers, E.B. Cathcart, E. Kumar, W. C. Dick andW. W. Buchanan, Ann. Rheum. Dis.31, 19 (1972).

    Google Scholar 

  4. I. M. Chalmers, M.A. Bell andW.W. Buchanan, Ann. Rheum. Dis.32, 58 (1973).

    PubMed  Google Scholar 

  5. E.M. Glenn, B.J. Bowman, W.M. Kooyers, T. Koslowske andM.L. Myers, J. Pharmac. exp. Ther.155, 157 (1967).

    Google Scholar 

  6. E.M. Glenn, B.J. Bowman andT.C. Koslowske, Biochem. Pharmac., Special Suppl.27 (1968).

  7. E.M. Glenn andB.J. Bowman, Proc. Soc. exp. Biol. Med.130, 2061 (1969).

    Google Scholar 

  8. E.M. Glenn, B.J. Bowman, S.C. Lyster andN.A. Rohloff, Proc. Soc. exp. Biol. Med.138, 235 (1971).

    PubMed  Google Scholar 

  9. E.M. Glenn, Proc. Soc. exp. Biol. Med.129 860 (1968).

    PubMed  Google Scholar 

  10. E.M. Glenn, J. Wilks andB.J. Bowman, Proc. Soc. exp. Biol. Med.141, 879 (1972).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. The Upjohn Company, 49001, Kalamazoo, Michigan

    E. Myles Glenn, Norman Rohloff, Barbara J. Bowman & Stanley C. Lyster

Authors
  1. E. Myles Glenn
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  2. Norman Rohloff
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  3. Barbara J. Bowman
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  4. Stanley C. Lyster
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Glenn, E.M., Rohloff, N., Bowman, B.J. et al. The pharmacology of 2-(2-fluoro-4-biphenylyl)Propionic acid (Flurbiprofen) A potent non-steroidal anti-inflammatory drug. Agents and Actions 3, 210–216 (1973). https://doi.org/10.1007/BF01968544

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  • DOI: https://doi.org/10.1007/BF01968544

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