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Choleretic and cholestatic effects of infused bile salts in the rat

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Summary

In rats, at low infusion rates taurocholate (TC), taurochenodeoxycholate (TCDC) and taurodeoxycholate (TCD) each produced an increase in bile flow of 20–50%. However, at high infusion rates (5–20 μmoles min−1 kg−1) the cholestatic effects of the bile salts were revealed and the relative toxicity of the bile salts was seen to be TDC>TCDC>TC.

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Author notes

  1. R. Drew

    Present address: Department of Clinical Pharmacology, Flinders University of South Australia, 5042, Bedford Park, South Australia

Authors and Affiliations

  1. Department of Human Physiology and Pharmacology, The University of Adelaide, 5001, Adelaide, South Australia

    R. Drew & B. G. Priestly

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  1. R. Drew
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  2. B. G. Priestly
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Drew, R., Priestly, B.G. Choleretic and cholestatic effects of infused bile salts in the rat. Experientia 35, 809–811 (1979). https://doi.org/10.1007/BF01968265

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  • DOI: https://doi.org/10.1007/BF01968265

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