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Cardiovascular effects of burimamide and metiamide

  • Histamine and Kinins
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Abstract

In anaesthetized gastric fistula cats with a histamine infusion running the effect of the histamine H2-receptor antagonists burimamide and metiamide on blood pressure and cardiac frequency was investigated.

Burimamide causes a rise in blood pressure and an increase in cardiac frequency. Metiamide has almost no blood pressure effect, but it lowers cardiac frequency.

In animals pretreated with mepyramine or phenoxybenzamine both burimamide and metiamide elevate the blood pressure lowered by histamine and has no or a lowering effect on cardiac frequency, respectively.

It is concluded from the experiments that

  1. (1)

    burimamide like histamine releases catecholamines,

  2. (2)

    metiamide is free of catecholamine releasing properties, and

  3. (3)

    blood vessels responsible for the general blood pressure contain at least predominatly or exclusively histamine H2-receptors.

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References

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Authors and Affiliations

  1. Department of Pharmacology, University of Tübingen, Federal Republic of Germany

    Margittá Albinus & K. -F. Sewing

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  1. Margittá Albinus
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  2. K. -F. Sewing
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Supported by a grant from the Deutsche Forschungsgemeinschaft.

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Albinus, M., Sewing, K.F. Cardiovascular effects of burimamide and metiamide. Agents and Actions 4, 222–226 (1974). https://doi.org/10.1007/BF01965223

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  • DOI: https://doi.org/10.1007/BF01965223

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