Abstract
Unilateral antidromic stimulation of the rat's lumbar dorsal roots evoked plasma extravasation in the skin of the corresponding hindpaw. Identical antidromic stimulation of the contralateral dorsal roots 4–5 minutes prior to the stimulation inhibited this response by 49%. No inhibition occurred when time interval between the stimulations was 60 minutes. It is concluded that not only inflammatory, but antiinflammatory mediators are released in response to activation of the peripheral endings of primary afferent neurons.
Similar content being viewed by others
References
W. M. Bayliss,The Vaso-motor System. Longmans Green, London 1923.
J. L. Bonta,Endogenous modulators of the inflammatory response. InInflammation. Handbook of Experimental Pharmacology, vol. 50/I. (Eds. J. R. Vane and S. H. Ferreira) pp. 523–567, Springer, Berlin 1978.
C. A. Maggi and A. Meli,The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen. Pharmac.19, 1–43 (1988).
J. Szolcsányi,Capsaicin and neurogenic inflammation: history and early findings. InAntidromic Vasodilatation and Neurogenic Inflammation (Eds. L. A. Chahl, J. Szolcsànyi, and F. Lembeck) pp. 7–25, Akadémiai Kiadò, Budapest (1984).
J. Szolcsányi,Capsaicin-sensitive chemoceptive neural system with dual sensory-efferent function. InAntidromic Vasodilatation and Neurogenic Inflammation (Eds. L. A. Chahl, J. Szolcsànyi and F. Lembeck) pp. 27–55, Akadémiai Kiadò, Budapest 1984.
J. Szolcsànyi,Antidromic vasodilatation and neurogenic inflammation. Agents and Actions23, 4–11 (1988).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pintér, E., Szolcsànyi, J. Inflammatory and antiinflammatory effects of antidromic stimulation of dorsal roots in the rat. Agents and Actions 25, 240–242 (1988). https://doi.org/10.1007/BF01965023
Issue Date:
DOI: https://doi.org/10.1007/BF01965023