Skip to main content
SpringerLink
Log in

The effects of burimamide and metiamide on gastric secretion in the conscious cat

  • Histamine and Kinins
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

Burimamide has been shown to have an acid stimulating action in the conscious cat when injected during basal conditions. Metiamide does not stimulate gastric acid secretion and when injected in addition to burimamide reduces the acid secretion seen to that drug. These results suggest a possible partial agonist action of burimamide, an action not shared by metiamide.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. W. Black, W. A. M. Duncan, J. C. Emmett, C. R. Ganellin, T. Hesselbo, M. E. Parsons andJ. H. Wyllie,Metiamide — An Orally Active Histamine H 2-Receptor Antagonist, Agents and Actions3, 133–137 (1973).

    PubMed  Google Scholar 

  2. J. W. Black, W. A. M. Duncan, C. J. Durant, C. R. Ganellin andE. M. Parsons,Definition and Antagonism of Histamine H 2-Receptors, Nature236, 385–390 (1972).

    PubMed  Google Scholar 

  3. Margitta Albinus andK.-Fr. Sewing,Does Burimamide Inhibit Gastric Acid Secretion by a Release of Catecholamines?, Naunyn-Schmiedebergs Arch. Pharmak.279, 417–420 (1973).

    Google Scholar 

  4. D. Harris, J. D. Reed, J. R. Smy andC. W. Venables, J. Pharmac., in press (1974).

  5. S. Emas,Gastric Secretory Responses to Repeated Intravenous Infusions of Histamine and Gastrin in Anaesthetized and Non-Anaesthetized Gastric Fistula Cats, Gastroenterology,39, 771–780 (1960).

    PubMed  Google Scholar 

  6. S. Siegel,Nonparametric Statistics for the Behavioral Sciences (McGraw Hill).

  7. International Symposium on Histamine H 2-Receptor Antagonists (Eds. C. J. Wood, M. A. Simkins, London; Smith, Kline and French Ltd. 1973).

    Google Scholar 

  8. E. D. Jacobson,The Circulation of the Stomach, Gastroenterology48, 85–109 (1965).

    Google Scholar 

  9. F. Stadil andJ. F. Rhefeld,Release of Gastrin by Epinephrine in Man, Gastroenterology65, 210–215 (1973).

    PubMed  Google Scholar 

  10. H. Barth, I. Neimeyer andW. Lorenz,Studies on the Mode of Action of Histamine H 1-and H 2-Receptor Antagonists on Gastric Histamine Methyltransferase, Agents and Actions3, 138–147 (1973).

    PubMed  Google Scholar 

  11. K. M. Taylor,Comparison of the Antihistaminic Effect of Burimamide and Mepyramine and Their Effect on the Activity of Histamine Methyltransferase, Biochem. Pharmac.22, 2775–2776 (1973).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Pharmacy, Sunderland Polytechnic, Sunderland, England

    D. Harris & J. R. Smy

  2. Departments of Physiology and Surgery, University of Newcastle upon Tyne, England

    J. D. Reed & C. W. Venables

Authors
  1. D. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. R. Smy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. D. Reed
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. W. Venables
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harris, D., Smy, J.R., Reed, J.D. et al. The effects of burimamide and metiamide on gastric secretion in the conscious cat. Agents and Actions 4, 311–313 (1974). https://doi.org/10.1007/BF01964932

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01964932

Keywords

Search

Navigation