Abstract
Cardiac tumours have been frequently reported in patients with tuberous sclerosis but their incidence at different ages has been evaluated in only a few studies. We performed echocardiography in 47 children with tuberous sclerosis and found tumours in 22 (47%). In none, except one newborn, did we observe any clinical symptoms of heart failure. Tumours were more frequent in children below 2 years of age (91%) than in older children. As other signs of tuberous sclerosis are often absent in infants, echocardiography may be regarded as the most useful diagnostic test at this age. Follow up studies were done in 12 children and tumour regression occurred in 6 patients.
Similar content being viewed by others
Abbreviations
- TS :
-
tuberous sclerosis
References
Alkalay AL, Ferry DA, Lin B, Fink BW, Pomerance JJ (1987) Spontaneous regression of cardiac rhabdomyoma in tuberous sclerosis. Clin Pediatr 26: 532–535
Bass JL, Breningstall GN, Swaiman KF (1985) Echocardiographic incidence of cardiac rhabdomyoma in tuberous sclerosis. Am J Cardiol 55: 1379–1382
Farooki ZQ, Ross RD, Paridon SM, Humes RA, Karpowich PP, Pinsky WW (1991) Spontaneous regression of cardiac rhabdomyoma. Am J Cardiol 67: 897–899
Fenoglio JJ, McAllister HA, Ferrens VJ (1976) Cardiac rhabdomyoma: a clinicopathologic and electron-microscopic study. Am J Cardiol 38: 241–251
Gibbs JL (1985) The heart and tuberous sclerosis. An echocardiographic study. Br Heart J 54: 596–599
Gomez MZ (1988) Criteria for diagnosis. In: Gomez MR (ed) Tuberous sclerosis. Raven Press, New York, pp 9–21
Gresser CD, Shime J, Rakowski H, Smallhorn JF, Hui A, Berg JJ (1987) Fetal cardiac tumor: a prenatal echocardiographic marker for tuberous sclerosis. Am J Obstet Gynecol 156: 689–690
Harding CO, Pagon RA (1990) Incidence of tuberous sclerosis in patients with cardiac rhabdomyoma. Am J Med Genet 37: 443–446
Matsuoka Y, Nakati T, Kawaguchi K, Hayakawa K (1990) Disappearance of a cardiac rhabdomyoma complicating congenital mitral regurgitation as observed by serial two-dimensional echocardiography. Pediatr Cardiol 11: 98–101
Smith HC, Watson GH, Patel RG, Super M (1989) Cardiac rhabdomyomata in tuberous sclerosis: their course and diagnostic value. Arch Dis Child 64: 196–200
Wallace G, Smith HC, Watson GH, Rimmer S, D'Souza SW (1990) Tuberous sclerosis presenting with fetal and neonatal cardiac tumours. Arch Dis Child 65: 377–379
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jóźwiak, S., Kawalec, W., Dŀużewska, J. et al. Cardiac tumours in tuberous sclerosis: Their incidence and course. Eur J Pediatr 153, 155–157 (1994). https://doi.org/10.1007/BF01958974
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01958974