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Gigantecin: A novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, fromGoniothalamus giganteus (Annonaceae)

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Summary

Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid γ-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).

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Authors and Affiliations

  1. Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, 47907, West Lafayette, Indiana, USA

    A. Alkofahi, J. K. Rupprecht, Y. -M. Liu, C. -J. Chang, D. L. Smith & J. L. McLaughlin

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  1. A. Alkofahi
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  2. J. K. Rupprecht
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  3. Y. -M. Liu
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  4. C. -J. Chang
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  5. D. L. Smith
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  6. J. L. McLaughlin
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Alkofahi, A., Rupprecht, J.K., Liu, Y.M. et al. Gigantecin: A novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, fromGoniothalamus giganteus (Annonaceae). Experientia 46, 539–541 (1990). https://doi.org/10.1007/BF01954260

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  • DOI: https://doi.org/10.1007/BF01954260

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