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Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium

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Summary

Solid state fermentation systems were developed for the production of cephalosporins withStreptomyces clavuligerus andCephalosporium acremonium. S. clavuligerus NRRL 3585 was grown on moistened barley under optimum solid state fermentation conditions for 7 days; approximately 300 μg cephalosporins per g substrate were extracted from the kernels.C. acremonium C-10 produced approximately 950 μg cephalosporin C per g substrate after 10 days of solid state fermentation.

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Author notes

  1. M. F. G. Jermini

    Present address: Dipartimento Opere Sociali, Laboratorio Cantonale d'Igiene, CH-6904, Lugano, Switzerland

Authors and Affiliations

  1. Fermentation Microbiology Laboratory, Department of Biology, Massachusetts Institute of Technology, 02139, Cambridge, Massachusetts, USA

    M. F. G. Jermini & A. L. Demain

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  1. M. F. G. Jermini
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  2. A. L. Demain
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Jermini, M.F.G., Demain, A.L. Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium. Experientia 45, 1061–1065 (1989). https://doi.org/10.1007/BF01950159

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