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Conformations and biological properties of apomorphine and its phenanthro [10, 1-b, c] azepine homologue

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  • Pharmacologica
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Summary

11, 12-Dihydroxy-7-methyl-4, 5, 6, 7, 7a, 8-hexahydrophenanthro[10, 1-b, c]-azepine (2), a homologue of apomorphine (1), has been found to be devoid of dopaminergic effects. The biological differences between apomorphine and this homologue are explained in terms of differences in conformation of the two molecules.

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Author notes

  1. T. J. Petcher & H. P. Weber

    Present address: Pharmaceutical Division, Chemical Research, Sandoz Ltd., CH-4002, Basel, Switzerland

  2. D. Berney, J. Schmutz & T. G. White

    Present address: Research Institute, Wander AG, P. O. Box 2747, CH-3001, Bern, Switzerland

Authors and Affiliations

  1. Pharmaceutical Division, Chemical Research, Sandoz Ltd., CH-4002, Basel, Switzerland

    D. Berney, J. Schmutz & T. G. White

  2. Research Institute, Wander AG, P. O. Box 2747, CH-3001, Bern, Switzerland

    T. J. Petcher & H. P. Weber

Authors
  1. D. Berney
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  2. T. J. Petcher
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  3. J. Schmutz
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  4. H. P. Weber
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  5. T. G. White
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Additional information

16th Communication of seven-membered heterocycles; 15th Communication: J. Schmutz, Arzneimittel-Forsch. (Drug Res.)25, 712 (1975).

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Berney, D., Petcher, T.J., Schmutz, J. et al. Conformations and biological properties of apomorphine and its phenanthro [10, 1-b, c] azepine homologue. Experientia 31, 1327–1328 (1975). https://doi.org/10.1007/BF01945809

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  • DOI: https://doi.org/10.1007/BF01945809

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