Summary
A proposed intermediate in the metabolic transformation ofp-hydroxyphenylpyruvic acid into homogentisic acid has been synthetized. In an experiment with radioactive material in pig liver homogenate it could be shown that this compound does not occur as a free intermediate.
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References
B. Lindblad, G. Lindstedt andS. Lindstedt, J. Am. chem. Soc.92, 7446 (1970).
O. Neubauer, Dt. Arch. klin. Med.95, 211 (1909).
A. Neuberger, A. Rev. Biochem.18, 243 (1943).—L. A. Cohen andB. Witkop, Angew. Chem.73, 253 (1961).—S. Davies, G. L. Hassall andM. Schofield, J. chem. Soc. (C)1964, 3126;A. H. Soloway, J. theor. Biol.13, 100 (1966);B. L. Goodwin,tyrosine Catabolism (Clarendon Press, Oxford 1972).
S. Goodwin andB. Witkop, J. Am. chem. Soc.79, 179 (1957).
I. Saito, M. Yamane, H. Shimazu andT. Matsuura, Tetrahedron Lett.1975, 641.
J. I. Teng andL. L. Smith, J. Am. chem.95, 4060 (1973).
R. Lattrell, Ph. D. thesis, University of Munich, 1961.
R. Lattrell andE. Hecker, in preparation.
M. Traut andE. Hecker, Liebigs Ann. Chem.715, 214 (1968), and earlier publications.
J. Schweizer andE. Hecker, in press (1975).
A. I. Scott, P. A. Dodson, F. McCapra andM. B. Meyers, J. Am. chem. Soc.85, 3702 (1963);H. Iwasaki, L. A. Cohen andB. Witkop, ibid.85, 3701 (1963).
E. Hecker andE. Meyer, Chem. Ber.97, 1926 (1964);B. Miller, Mech. molec. Migration1, 247 (1968).
R. Lattrell andE. Hecker, in preparation.
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Schweizer, J., Lattrell, R. & Hecker, E. Conversion ofp-hydroxyphenylpyruvic acid into homogentisic acid: Possible participation ofp-quinol intermediates. Experientia 31, 1267–1268 (1975). https://doi.org/10.1007/BF01945771
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DOI: https://doi.org/10.1007/BF01945771