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MAO inhibition, an unlikely mode of action for chlordimeform

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Summary

Inhibition constants of several formamidines, their corresponding formanilides and other representatives of compounds derived from aniline, such as phenylureas, N-phenyl-carbamates and acylanilides, were determined for rat liver monoamine oxidase. The reversability of the inhibition and the lack of correlation between inhibition potencies and toxicities of the compounds tested add to the opinion that MAO inhibition is not a prominent factor in chlordimeform poisoning.

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Authors and Affiliations

  1. Agrochemicals Division, Ciba-Geigy Ltd., CH-4002, Basel, Switzerland

    R. Neumann & G. Voss

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  1. R. Neumann
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  2. G. Voss
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Neumann, R., Voss, G. MAO inhibition, an unlikely mode of action for chlordimeform. Experientia 33, 23–24 (1977). https://doi.org/10.1007/BF01936730

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