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The opposed influences ofβ-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

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Summary

The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong β-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with a new method for recording continuous frequency-force loops are presented.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Tübingen, Wilhelmstrasse 56, D-7400, Tübingen, Federal Republic of Germany

    D. Hilgemann, R. Englert & H. J. Mensing

Authors
  1. D. Hilgemann
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  2. R. Englert
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  3. H. J. Mensing
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Hilgemann, D., Englert, R. & Mensing, H.J. The opposed influences ofβ-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs. Experientia 33, 1629–1631 (1977). https://doi.org/10.1007/BF01934040

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