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Effect of chronic treatment with mescaline upon tissue levels of the drug

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Zusammenfassung

Bei chronisch behandelten Ratten war die Mescalin-Konzentration in Gehirn und Leber niedriger als bei akut behandelten Tieren. Die Hemmung der Monoaminooxydase durch Vorbehandlung mit Pargylin erhöhte signifikant die Mescalinmenge in der Leber. Ferner liessen die Untersuchungen den Schluss zu, dass die MAO oder andere Aminooxydasen, die durch Pargylin gehemmt werden, nicht die Hauptrolle bei den beobachteten Veränderungen in den Gewebekonzentrationen spielen.

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Author notes

  1. J. C. Winter

    Present address: Department of Pharmacology, Yale University, School of Medicine, 06510, New Haven, Connecticut, USA

Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, State University of New York, 122 Capen Hall, 14214, Buffalo, New York, USA

    V. H. Sethy & J. C. Winter

Authors
  1. V. H. Sethy
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  2. J. C. Winter
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Additional information

Acknowledgments. This work was supported in part by Research Grant No. 15406 from the National Institute of Mental Health. Dr. Sethy was the recipient of a Henry C. and Bertha H. Buswell Research Fellowship from the State University of New York at Buffalo.

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Sethy, V.H., Winter, J.C. Effect of chronic treatment with mescaline upon tissue levels of the drug. Experientia 29, 571–572 (1973). https://doi.org/10.1007/BF01926671

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