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Differences in tolerance to mescaline produced by peripheral and direct central administration

  • Original Investigations
  • Animal Studies
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Abstract

A fixed-ratio schedule of food reinforcement (FR 30) was used to study the differences in tolerance produced by peripheral injections and intraventricular infusions of mescaline hydrochloride in rats. Successive daily administrations of 10 mg mescaline/kg i.p. resulted in a decrease in behavioral disruption (tolerance). The following day, intraventricular infusion of a dose of mescaline previously shown to be approximately equal to the peripheral dose in terms of behavioral disruption was started. After tolerance to central administration of mescaline was established, 10 mg/kg of mescaline injected i.p. resulted in behavioral disruption equal to that produced by the first i.p. injection.

In a second experiment, blood pressure effects of mescaline given i.p. and intraventricularly were studied. Peripherally administered mescaline produced marked effects on caudally measured blood pressure and increased biting upon and struggling within the restraining device. Mescaline administered centrally did not appear to elicit similar cardiovascular changes. These data suggest that different mechanisms may be involved in the formation of tolerance to mescaline administered by these two routes as measured by means of a fixed ratio reinforcement schedule.

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Authors and Affiliations

  1. Department of Pharmacology and Psychiatry Research Unit, 55455, Minneapolis, Minnesota, USA

    H. A. Tilson & S. B. Sparber

  2. Department of Psychiatry, University of Minnesota, 55455, Minneapolis, Minnesota, USA

    H. A. Tilson & S. B. Sparber

Authors
  1. H. A. Tilson
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  2. S. B. Sparber
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Supported in part by a Grant from the USPHS-MH-08565. H.A.T. is a predoctoral fellow in the Department of Psychology, University of Minnesota

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Tilson, H.A., Sparber, S.B. Differences in tolerance to mescaline produced by peripheral and direct central administration. Psychopharmacologia 19, 313–323 (1971). https://doi.org/10.1007/BF00404375

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  • DOI: https://doi.org/10.1007/BF00404375

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