Summary
The hypotheses dealing with mechanisms of neurulation are reviewed briefly. The phenomenon of interkinetic nuclear migration is thought to be an important factor to be considered in the invagination of the neuroepithelium in the chick embryo. Evidence is presented that implicates cytoplasmic microtubules in this phenomenon. It is suggested that microtubules not only participate in cell elongation but also that they are involved, through interkinetic nuclear migration, in the broadening of the basal region of the cells; this widening progressively creates the strain that ensures the invagination of the neuroepithelium.
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Acknowledgments. This work is supported by the MRC of Canada. We are grateful to C. Auclair for his invaluable collaboration and to Miss H. Stephens for her help in improving the English composition of this text.
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Messier, PE. Microtubules, interkinetic nuclear migration and neurulation. Experientia 34, 289–296 (1978). https://doi.org/10.1007/BF01922992
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DOI: https://doi.org/10.1007/BF01922992