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Relation between stimulus intensity and neutrophil chemotactic response

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Summary

The effect of chemotactic peptides which lack chemokinetic activity has been investigated. The neutrophil response is proportional to the logarithm of the stimulus intensity, or alternatively a power function with an exponent of 0.3. Equal responses are obtained for equal ratios between the peptide concentration in the lower compartment and the threshold concentration. The significance of Weber-Fechner's law in leucocyte chemotaxis is discussed.

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Author notes

  1. J. H. Wissler

    Present address: Arbeitsgruppe Biochemie, Abteilung für experimentelle Kardiologie, Max-Planck-Institut für physiologische und klinische Forschung, D-6350, Bad Nauheim, Germany

Authors and Affiliations

  1. Department of Pathology, University of Bern, Freiburgstrasse 30, CH-3010, Bern, Switzerland

    H. U. Keller, J. H. Wissler, M. W. Hess & H. Cottier

  2. Arbeitsgruppe Biochemie, Abteilung für experimentelle Kardiologie, Max-Planck-Institut für physiologische und klinische Forschung, D-6350, Bad Nauheim, Germany

    H. U. Keller, M. W. Hess & H. Cottier

Authors
  1. H. U. Keller
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  2. J. H. Wissler
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  3. M. W. Hess
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  4. H. Cottier
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Additional information

We thank Miss B. Zanolari, Mrs M. Marti, Mrs Hauck and Mr Dietz for excellent technical assistance. This work was supported by the Swiss National Foundation for Scientific Research.

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Keller, H.U., Wissler, J.H., Hess, M.W. et al. Relation between stimulus intensity and neutrophil chemotactic response. Experientia 33, 534–536 (1977). https://doi.org/10.1007/BF01922257

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