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Evaluation and Action of Biological Activity of Mediators Generated from Normal Serum by Interaction with Foreign Macromolecules

  • Chapter
Gram-Negative Bacterial Infections and Mode of Endotoxin Actions

Abstract

Plasma and serum components and their metabolic products are uniquely distributed and ubiquitously present in intimate contact with the cells of the host. They inevitably participate in reactions occurring on cell membranes and in the fluid phase of the interstices. Structural alterations and the local or systemic change in their concentration, induced by internal or external factors, and the concomitant emergence of new compounds, represent the humoral signals, interplaying with the body’s cellular components and triggering them in a regulatory manner to display their genetically determined functions. In response to these humoral signals, a cell may either release new substances or physically influence the fluid phase and thus further alter the normal physiological environment for itself and for other cells. These processes do not occur randomly; rather, they follow regulatory principles. Otherwise, the process of serum or plasma protein alteration and the uncontrolled accumulation of cell-generated mediators could lead to fatal shock, hypersensitivity or autoimmune reactions. Since a considerable proportion of the population is constantly suffering from these and related diseases (1), the evaluation and knowledge of regulatory principles of the process of serum protein alteration, the mechanism of biological action of the concomitantly generated products, and of the interplay of cells with their (mediator-) changed environment (recognition and response of cells) are relevant areas of research, especially from the socio-economic view point.

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References

  1. Davis, D. J.: J. Allergy clin. Immunol. 49: 323 (1972).

    Article  PubMed  CAS  Google Scholar 

  2. Kadis, S., Weinbaum, G., Ajl, S. J.: Microbial toxins, a comprehensive treatise. Bacterial endotoxins, vol. 4 ( Academic Press, New York 1971 ).

    Google Scholar 

  3. Kadis, S., Weinbaum, G., Ajl, S. J.: Microbial toxins, a comprehensive treatise. Bacterial endotoxins, vol. 5 ( Academic Press, New York 1971 ).

    Google Scholar 

  4. Landy, M., Braun, W.: Bacterial endotoxins. ( Rutgers University Press, New Brunswick 1964 ).

    Google Scholar 

  5. Landy, M.: The significant immunological features of bacterial endotoxins. In: Wolstenholme, G. E. W., Birch, J.: Pyrogens and fever, p. 49 ( Churchill and Livingstone, London 1971 ).

    Google Scholar 

  6. Work, E.: Production, chemistry and properties of bacterial pyrogens and endotoxins. In: Wolstenholme, G. E. W., Birch, J.: Pyrogens and fever, p. 23 ( Churchill and Livingstone, London 1971 ).

    Google Scholar 

  7. Brown, D. L., Lachmann, P. J.: Trans. Coll. Int. Allergologicum 45: 193 (1973).

    CAS  Google Scholar 

  8. Agarwal, M. K.: Int. Arch. Allergy 44: 759 (1973).

    Article  PubMed  CAS  Google Scholar 

  9. Gewurz, H.: Alternate pathways to activation of the complement system. In: Ingram, D. G.: Biological activities of complement, p. 56 ( Karger, Basel 1972 ).

    Google Scholar 

  10. Jensen, J. A.: Anaphylatoxin (s). In: Ingram, D. G.: Biological activities of complement, p. 136 ( Karger, Basel 1972 ).

    Google Scholar 

  11. Melmon,.K. L., Epstein, W., Tan, M., Nies, A. L.: Kinin generation caused by two immunologic systems (human IgG-rheumatoid factor complex and endotoxin-antibody-complement complex). In: Movat, H. Z.: Cellular and humoral mechanisms in anaphylaxis and allergy, p. 224 ( Karger, Basel 1969 ).

    Google Scholar 

  12. Pillemer, L., Blum, L., Lepow, I. H., Ross, O. A., Todd, E. W., Wardlaw, A. C.: Science 120: 279 (1954).

    Article  PubMed  CAS  Google Scholar 

  13. Nelson Jr., R. A.: J. exp. Med. 108: 515 (1958).

    Article  PubMed  CAS  Google Scholar 

  14. Snyderman, R., Shin, H. S., Phillips, J. K., Gewurz, H., Mergenhagen, S. E.: J. Immunol. 103: 413 (1969).

    PubMed  CAS  Google Scholar 

  15. Jensen, J. A., Snyderman, R., Mergenhagen, S. E.: Chemotactic activity, a property of guinea pig C’5-anaphylatoxin. In: Movat, H. Z.: Cellular and humoral mechanisms in anaphylaxis and allergy, p. 265 ( Karger, Basel 1969 ).

    Google Scholar 

  16. Frank, M. M., Kane, M. A., May, J. E.: Biological interactions of complement with endotoxin: Studies in C4-deficient guinea pigs. In: Braun, W., Ungar, J.: Non-specific factors influencing host resistance, a reexamination, p. 323 ( Karger, Basel 1973 ).

    Google Scholar 

  17. Gewurz, H., Ertel, N.: Non-immune activation of complement: Two new phenomena. In: Braun, W., Ungar, J.: Non-specific factors influencing host resistance, a reexamination, p. 340 ( Karger, Basel 1973 ).

    Google Scholar 

  18. Elfin, R. J., Wolff, S. M.: Endotoxin-induced non-specific resistance to infection - a possible mechanism. In: Braun, W., Ungar, J.: Non-specific factors influencing host resistance, p. 371 ( Karger, Basel 1973 ).

    Google Scholar 

  19. Mustard, J. F., Evans, G., Packham, M. A., Nishizawa, E. E.: The platelet in intravascular immunological reactions. In: Movat, H. Z.: Cellular and humoral mechanisms in anaphylaxis and allergy, p. 151 ( Karger, Basel 1969 ).

    Google Scholar 

  20. Gewurz, H., Shin, H. S., Mergenhagen, S. E.: J. exp. Med. 128: 1049 (1963).

    Article  Google Scholar 

  21. Davis, S. D., Ianetta, A., Wedgwood, R. J.: Bactericidal reactions of serum. In: Ingram, D. G.: Biological activities of complement, p. 43 ( Karger, Basel 1972 ).

    Google Scholar 

  22. Havemann, K., Horvat, M., Sodomann, C. -P., Havemann, K., Bürger, S.: Europ. J. Immunol. 2: 97 (1972).

    Google Scholar 

  23. Erdös, E. G., Wilde, A. F.: Bradykinin, kallidin and kallikrein. In: Eichler, O., Farah, A., Herken, H., Welch, A. D.: Handbook of experimental pharmacology, vol. 25 ( Springer, Berlin 1970 ).

    Google Scholar 

  24. Rocha e Silva, M.: Histamine and anti-histaminics. In: Eichler, O., Farah, A.: Handbook of experimental pharmacology, vol. 18/1 ( Springer, Berlin 1966 ).

    Google Scholar 

  25. Wissler, J. H., Sorkin, E.: Mechanism of cellular recognition and chemotactic activity for neutrophil leukocytes. Abstr. Commun. 9th Int. Congr. Biochem., p. 318, Stockholm 1973.

    Google Scholar 

  26. Wissler, J. H.: Europ. J. Immunol. 2: 84 (1972).

    Google Scholar 

  27. Wissler, J. H., Sorkin, E. : Nature and mechanism of cellular recognition and regulation of leukocyte migration. Workshop report : Chemotaxis of leukocytes, Paris 1973, Nouv. rev. française d’hématol., in press.

    Google Scholar 

  28. Wissler, J. H. : The binary leukotactic peptide system of serum as a model for exploring cellular recognition and leukocytes-migratory behaviour: In : Sorkin, E. : Chemotaxis of leukocytes, its biology and biochemistry (Karger, Basel 1974), in press.

    Google Scholar 

  29. Wissler, J. H.: Experientia 27: 1147 (1971).

    Article  Google Scholar 

  30. Wissler, J. H.: Europ. J. Immunol. 2: 73 (1972).

    Article  CAS  Google Scholar 

  31. Wissler, J. H., Stecher, V. J., Sorkin, E.: Europ. J. Immunol. 2: 90 (1972).

    Article  CAS  Google Scholar 

  32. Wissler, J. H., Stecher, V. J., Sorkin, E.: Int. Arch. Allergy 42: 722 (1972).

    Article  PubMed  CAS  Google Scholar 

  33. Wissler, J. H., Stecher, V. J., Sorkin, E.: Regulation of chemotaxis of leukocytes by the anaphylatoxin-related peptide system. In: Peeters, H.: Proc. XXth Colloquium Protides of the Biological Fluids, p. 411 ( Pergamon Press, Oxford 1973 ).

    Google Scholar 

  34. Sorkin, E., Stecher, V. J., Borel, J. F.: Ser. Haematol., vol. 3/1: 131 (1970).

    Google Scholar 

  35. Giertz, H., Hahn, F.: Makromolekulare Histaminliberatoren. In: Eichler, O., Farah, A.: Handbook of experimental pharmacology, vol. 18/1, p. 481 ( Springer, Berlin 1966 ).

    Google Scholar 

  36. Bodammer, G., Vogt, W.: Arch. Pharmacol. Exp. Path. 266: 255 (1970).

    Google Scholar 

  37. Snyderman, R., Mergenhagen, S. E.: Characterization of polymorphonuclear leukocyte chemotactic activity in serums activated by various inflammatory agents. In: Ingram, D. G.: Biological activities of complement, p. 117 ( Karger, Basel 1972 ).

    Google Scholar 

  38. Udaka, K., Udaka, K.: Fed. Proc. 31: 657 (1972).

    Google Scholar 

  39. Keller, H. U., Sorkin, E.: Immunology 9: 441 (1965).

    Google Scholar 

  40. Wissler, J. H., Stecher, V. J., Sorkin, E.: J. Immunol. 111: 314 (1973).

    Google Scholar 

  41. Wilkinson, P. C., McKay, I. C.: Int. Arch. Allergy 41: 237 (1971).

    Article  PubMed  CAS  Google Scholar 

  42. Wilkinson, P. C., McKay, I. C.: Europ. J. Immunol 2: 570 (1972).

    Article  CAS  Google Scholar 

  43. Bessis, M. : Necrotaxis : chemotaxis towards an injured cell. Nouv. Rev. Française d’Hématol., in press.

    Google Scholar 

  44. Wilkinson, P. C.: Nature 244: 512 (1973).

    Article  PubMed  CAS  Google Scholar 

  45. Pick, E., Turk, J. L.: Clin. exp. Immunol. 10: 1 (1972).

    PubMed  CAS  Google Scholar 

  46. Bokisch, V. A., Müller-Eberhard, H. J., Cochrane, C. G.: J. exp. Med. 129: 1109 (1969).

    Article  PubMed  CAS  Google Scholar 

  47. Müller-Eberhard, H. J.: Annu. Rev. Biochem. 38: 389 (1969).

    Article  PubMed  Google Scholar 

  48. Müller-Eberhard, H. J., Vallota, E. H., Götze, O., Zimmermann, T. S.: Mediators of the inflammatory response-complement. In: Lepow, I. H., Ward, P. A.: Inflammation, mechanisms and control, p. 83 ( Academic Press, New York 1972 ).

    Google Scholar 

  49. Vallota, E. H., Müller-Eberhard, H. J.: J. exp. Med. 137: 1109 (1973).

    Article  PubMed  CAS  Google Scholar 

  50. Shin, H. S., Snyderman, R., Friedman, E., Mellors, A., Mayer, M. M.: Science 162: 361 (1968).

    Article  PubMed  CAS  Google Scholar 

  51. Snyderman, R., Shin, H. S., Hausman, M. H.: J. Immunol. 107: 316 (1971).

    Google Scholar 

  52. Snyderman, R., Shin, H. S., Hausman, M. H.: Proc. Soc. exp. Biol. Med. 138: 387 (1971).

    PubMed  CAS  Google Scholar 

  53. Keller, H. U., Sorkin, E.: Int. Arch. Allergy 31: 505 (1967).

    Article  Google Scholar 

  54. Keller, H. U., Sorkin, E.: Int. Arch. Allergy 31: 575 (1967).

    Article  PubMed  CAS  Google Scholar 

  55. Keller, H. U., Sorkin, E.: Int. Arch. Allergy 35: 279 (1969).

    Article  PubMed  CAS  Google Scholar 

  56. Wissler, J. H. , Sorkin, E. , Jungi, T. W. , Stecher, V. J. , Arcon, A. : Mechanisms regulating leukocyte accumulation : cellular recognition and migratory behaviour of phagocytes. Proc. Int. Meeting on Future Trends in Inflammation, Verona 1973, in press. Abstr. Commun., p. 11.

    Google Scholar 

  57. Giertz, H.: Pharmacology of anaphylatoxin. In: Movat, H. Z.: Cellular and humoral mechanisms in anaphylaxis and allergy, p. 253 ( Karger, Basel 1969 ).

    Google Scholar 

  58. Bloom, B. R., David, J. R.: Elaboration of effector molecules by activated lymphocytes. In: Lawrence, H. S., Landy, M.: Mediators of cellular immunity, p. 247 ( Academic Press, New York 1969 ).

    Google Scholar 

  59. Jensen, J.: Science 155: 1122 (1967). Ibid: Immunochemistry 3: 498 (1966).

    Google Scholar 

  60. Cochrane, C. G., Müller-Eberhard, H. J.: J. exp. Med. 127: 371 (1968).

    Google Scholar 

  61. Bloom, B. R., Glade, P. R. : In vitro methods in cell-mediated immunity (Academic Press, New York 1971).

    Google Scholar 

  62. David, J. R.: Fed. Proc. 30: 1730 (1971).

    PubMed  CAS  Google Scholar 

  63. Ward, P. A., Zvaifler, N. J.: J. clin. Invest. 50: 606 (1971).

    Article  PubMed  CAS  Google Scholar 

  64. Zvaifler, N. J.: Arth. Rheum. 13: 895 (1970).

    Article  CAS  Google Scholar 

  65. Cochrane, C. G.: The Arthus reaction. In: Zweifach, B. W., Grant, L., McCluskey, R. T.: The inflammatory process, p. 613 ( Academic Press, New York 1965 ).

    Google Scholar 

  66. Lee, L., Stetson Jr., C. A.: The local and generalized Shwartzman phenomena. In: Zweifach, B. W., Grant, L., McCluskey, R. T.: The inflammatory process, p. 791 ( Academic Press, New York 1965 ).

    Google Scholar 

  67. Nowotny, A. (Ed.) : Molecular biology of gram-negative bacterial lipopolysaccharides. Ann. N. Y. Acad. Sci. 133 (1966), various review articles.

    Google Scholar 

  68. Cotran, R. S., Remensnyder, J. P.: Ann. N. Y. Acad. Sci. 150: 495 (1968).

    Article  PubMed  CAS  Google Scholar 

  69. Markley, K.: Ann. N. Y. Acad. Sci. 150: 922 (1968).

    Article  PubMed  CAS  Google Scholar 

  70. Bernauer, W., Hahn, F., Wissler, J. H., Nimptsch, P., Filipowski, P.: Arch. Pharmakol. exp. Path. 269: 413 (1971).

    Google Scholar 

  71. Bernauer, W., Hahn, F., Nimptsch, P., Wissler, J. H.: Int. Arch. Allergy 42: 136 (1972).

    Article  PubMed  CAS  Google Scholar 

  72. Parish, W. E.: Clin. Allergy 2: 381 (1972).

    Article  PubMed  CAS  Google Scholar 

  73. Spector, W. G., Willoughby, D. A.: Chemical Mediators II. In: Zweifach, B. W., Grant, L., McCluskey, R. T.: The inflammatory process, p. 427 ( Academic Press, New York 1965 ).

    Google Scholar 

  74. Miller, M. E., Oski, F. A., Harris, M. B.: Lancet I: 665 (1971).

    Article  Google Scholar 

  75. Clark, R. A., Kimball, H. R.: J. clin. Invest. 50: 2645 (1971).

    Article  PubMed  CAS  Google Scholar 

  76. Buckley, I. K.: Exp. Mol. Path. 2: 402 (1963).

    Article  Google Scholar 

  77. Hurley,J. V. : Ann. N. Y. Acad. Sci. 116 : 918 (1964).

    Article  PubMed  CAS  Google Scholar 

  78. Brier, A. M., Snyderman, R., Mergenhagen, S. E., Notkins, A. L.: Science 170: 1104 (1970).

    Article  PubMed  CAS  Google Scholar 

  79. Hahn, F.: Excerpta med. Int. Congr. Ser. 162: 145 (1968).

    Google Scholar 

  80. Bernauer, W., Hahn, F., Beck, E., Kury, H.: Arch. Pharmak. exp. Path. 266: 208 (1970).

    CAS  Google Scholar 

  81. Seyle, H.: The mast cell, pp. 16 and 133 ( Butterworth, Washington 1965 ).

    Google Scholar 

  82. Jensen, J. A., Davies, D., Linn, B. S., Snyderman, R., Franklin, L.: Circulat. Res. 30: 332 (1972).

    PubMed  CAS  Google Scholar 

  83. Winn, H. J., Baldamus, C. A., Jooste, S. V., Russell, P. S.: J. exp. Med. 137: 893 (1973).

    Article  PubMed  CAS  Google Scholar 

  84. Sorkin, E., Stecher, V. J., Wissler, J. H.: The anaphylatoxin-related leukotactic binary peptide system. In: Braun, W., Ungar, J.: Non-specific factors influencing host resistance, a reexamination, p. 196 ( Karger, Basel 1973 ).

    Google Scholar 

  85. Monod, J., Changeux, J. -P., Jacob, F.: J. molec. Biol. 6: 306 (1963).

    Article  PubMed  CAS  Google Scholar 

  86. Monod, J., Wyman, J., Changeux, J. -P.: J. molec. Biol. 12: 88 (1965).

    Article  PubMed  CAS  Google Scholar 

  87. Neumann, E.: Angew. Chemie, Int. Ed. 12: 356 (1973).

    Article  CAS  Google Scholar 

  88. Wissler, J. H., Stecher, V. J., Sorkin, E., Jungi, Th.: Mechanism of leukotaxis. Abstr. Commun. 4th Tagung der Gesellschaft für Immunologie, p. 61, Berne 1972.

    Google Scholar 

  89. Wilhelm, D. L.: Chemical mediators I. In: Zweifach, B. W., Grant, L., McCluskey, R. T.: The inflammatory process, p. 389 ( Academic Press, New York 1965 ).

    Google Scholar 

  90. David, J. R., Al-Askari, S., Lawrence, H. S., Thomas, L.: J. Immunol. 93: 264 (1964).

    PubMed  CAS  Google Scholar 

  91. George, M., Vaughan, J. H.: Proc. Soc. exp. Biol. Med. 111: 514 (1962).

    PubMed  CAS  Google Scholar 

  92. Schilling, J. A.: Physiol. Rev. 48: 374 (1968).

    PubMed  CAS  Google Scholar 

  93. Cohen, S., Ward, P. A.: J. exp. Med. 133: 133 (1971).

    Article  PubMed  CAS  Google Scholar 

  94. Keller, H. U., Borel, J. F., Wilkinson, P. C., Hess, M. W., Cottier, H.: J. Immunol. Methods 1: 165 (1972).

    Article  PubMed  CAS  Google Scholar 

  95. Jensen, J. A. , Williams, D. : Chemotaxis of human neutrophils induced by lymphocytoxic sera. Nouv. Rev. Française d’Hématol. , in press.

    Google Scholar 

  96. Müller-Eberhard, H. J., Vallota, E. H.: Formation and inactivation of anaphylatoxins. In: Austen, K. F., Becker, E. L.: Biochemistry of the acute allergic reactions, p. 217 ( Blackwell Scientific Publications, Oxford 1971 ).

    Google Scholar 

  97. Lichtenstein, L. M., Gewurz, H., Adkinson Jr., N. F., Shin, H. S., Mergenhagen, S. E.: Immunology 16: 327 (1969).

    PubMed  CAS  Google Scholar 

  98. Gewurz, H., Pickering, R. J., Snyderman, R., Lichtenstein, L. M., Good, R. A.: J. exp. Med. 131: 817 (1970).

    Article  PubMed  CAS  Google Scholar 

  99. Gewurz, H., Snyderman, R., Mergenhagen, S. E., Shin, H. S.: Effects of endotoxic lipopolysaccharides on the complement system. In: Kadis, S., Weinbaum, G., Ajl, S. J.: Microbial toxins, vol. 5, p. 127 ( Academic Press, New York 1971 ).

    Google Scholar 

  100. Fine, D. P.: J. Immunol. 112: 763 (1974).

    PubMed  CAS  Google Scholar 

  101. Ferrone, S., Cooper, N. R., Pellegrino, M. A., Reisfeld, R. A.: Proc. nat. Acad. Sci. 70: 3665 (1973), J. Immunol. 111: 301 (1973).

    Google Scholar 

  102. Juby, P. F., Hudyma, T. W.: Non-steroidal antiinflammatory agents. In: Cain, C. K., p. 182 ( Academic Press, New York 1971 ).

    Google Scholar 

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  1. J. H. Wissler
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Editors and Affiliations

  1. Abteilung für Immunologie und Serologie am Institut für Hygiene und Medizinische Mikrobiologie der Fakultät für Klinische Medizin Mannheim, Universität Heidelberg, Mannheim, Federal Republic of Germany

    Bernhard Urbaschek  & Renate Urbaschek  & 

  2. Departments of Microbiology and Pediatrics, State University of New York at Buffalo, Buffalo, N.Y., USA

    Erwin Neter M. D.

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Wissler, J.H. (1975). Evaluation and Action of Biological Activity of Mediators Generated from Normal Serum by Interaction with Foreign Macromolecules. In: Urbaschek, B., Urbaschek, R., Neter, E. (eds) Gram-Negative Bacterial Infections and Mode of Endotoxin Actions. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8396-0_14

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  • DOI: https://doi.org/10.1007/978-3-7091-8396-0_14

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