Summary
Using the modified technique of transplantation test, ITR serum activity was found in most (14 out of 21) individual hamster sera obtained during the latent period of primary SV40 carcinogenesis (60 days after virus infection when newborn). On the other hand, as a rule, no ITR activity was observed in the sera of the same hamsters after tumor appearance and during their growth. ITR activity rapidly disappeared from sera of hamsters neonatally infected with SV40 after their successful immunization with the same virus during the latent period. There appears to be a correlation between the presence of ITR serum factor during the latent period and the subsequent primary SV40 tumor appearance in hamsters.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. E. Hellström and I. Hellström, in: Advances in Immunology, vol. 18, p. 209. Ed. F. J. Dixon and H. G. Kunkel. Academic Press, New York 1974
G. H. Heppner, in: Immunological Aspects of Neoplasia. Series Haematologica, vol. 5, p. 41. Ed. K. G. Jensen and S. A. Killmann. Munksgaard, Copenhagen 1972.
H. O. Sjögren, in: Methods in Cancer Research, vol. 10, p. 19. Ed. H. Busch. Academic Press, New York 1973.
R. W. Baldwin, M. J. Embleton, M. R. Price and R. A. Robins, Cancer34, Suppl.1, 1452 (1974).
G. Steele, Jr, H. O. Sjögren, J. E. Rosengren, C. Lindström, A. Larsson and L. Leandoer, J. nat. Cancer Inst.54, 959 (1975).
R. W. Baldwin and R. A. Robins, Br. Med. Bull.32, 118 (1976).
I. Hellström and K. E. Hellström, in: In vitro Methods in Cell-Mediated and Tumor Immunity, p. 533. Ed. B. R. Bloom and J. R. David. Academic Press, New York 1976.
The abbreviations used are: SV40, simian vacuolating virus 40; NHS, normal hamster sera; TCID50, median tissue-culture infective dose; ITR, serum activity inhibiting transplantation resistance; TrD50, dose of tumor cells causing growth of transplanted tumors in 50% of the animals; RI, a resistance index; L60, sera obtained from hamsters SV40-infected when newborn during the latent period 60 days after birth; L81, sera obtained from hamsters 21 days after immunization with SV40 during the latent period (81 days after birth); T0, sera obtained from the hamsters at the day of appearance of palpable primary tumors; T18–36 and T45–57, sera obtained from the hamsters on 18–36th and 45–57th days of the primary tumors growth respectively; SD, standard deviation.
J. H. Coggin, Jr, K. R. Ambrose, P. J. Dierlam and N. G. Anderson, Cancer Res.34, 2092 (1974).
M. H. Goldrosen and P. B. Dent, Fed. Proc.34, 1041 (1975), Abstract.
M. H. Goldrosen and P. B. Dent, Br. J. Cancer32, 667 (1975).
J. W. Blasecki, Fed. Proc.35, 226 (1976), Abstract.
S. O. Prather and R. N. Lausch, Int. J. Cancer17, 380 (1976).
S. O. Prather and R. N. Lausch, Int. J. Cancer18, 820 (1976).
E. A. Volpe, Neoplasma, Bratisl.23, 345 (1976).
G. I. Deichman and T. E. Kluchareva, Nature, Lond.202, 1126 (1964).
G. I. Deichman and T. E. Kluchareva, Virology24, 131 (1964).
G. I. Deichman and T. E. Kluchareva, J. nat. Cancer Inst.36, 647 (1966).
G. I. Deichman, in: Advances in Cancer Research, vol. 12, p. 101. Ed. G. Kelin and S. Weinhouse. Academic Press, New York 1969.
E. A. Volpe, Vest. Akad. med. Nauk SSSR, No. 2, 26 (1976).
L. J. Reed and H. Muench, Am. J. Hyg.27, 493 (1938).
K. R. Ambrose, N. G. Anderson and J. H. Coggin, Jr, Nature, Lond.233, 321 (1971).
Author information
Authors and Affiliations
Additional information
Acknowledgment. The author wishes to thank Dr Galina I. Deichman for continuing advice and encouragement during the course of these studies.
Rights and permissions
About this article
Cite this article
Volpe, E.A. Serum activity inhibiting specific simian virus 40-induced transplantation resistance and its correlation with primary SV40 tumors appearance in hamsters. Experientia 34, 113–116 (1978). https://doi.org/10.1007/BF01921935
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01921935