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Changes in cAMP concentrations during chronic cardiac hypertrophy

Änderungen der Konzentration von cAMP während chronischer Herzhypertrophie

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Summary

Mild pulmonic stenosis in the dog, where right ventricular peak systolic pressure was increased approximately 150% at the time of sacrifice, induced 100% or more increase in right ventricular free wall weight by 3 weeks postoperative. Accompanying cardiac hypertrophy at these postoperative times, there was a decrease in both tissue PO2 levels and cAMP concentrations in the hemodynamically stressed ventricle, the right ventricle. Myosin ATPase activity was elevated as well as the velocity of contractile element shortening. The hemodynamically nonstressed left ventricle did not hypertrophy at these early postoperative times.

Zusammenfassung

3 Wochen nach Operation verursachte eine milde Stenosierung der Pulmonalarterie mit Steigerung der systolischen Spitzendrucke im rechten Ventrikel um 150% beim Hund einen 100% igen oder stärkeren Anstieg im Gewicht der freien Wand des rechten Ventrikels. Als Begleiterscheinung der Herzhypertrophie ergab sich um diese Zeit ein Rückgang sowohl des Gewebe-Sauerstoffpartialdruckes als auch der Konzentration von cAMP im hämodynamisch mehrbeanspruchten (rechten) Ventrikel. Die ATPase-Aktivität von Myosin war erhöht, desgleichen die Verkürzungsgeschwindigkeit des kontraktilen Elements. Der hämodynamisch nicht mehrbeanspruchte linke Ventrikel zeigte in diesem frühen postoperativen Stadium keine Hypertrophie.

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Author notes

  1. J. Wikman-Coffelt Ph.D.

    Present address: Section of Cardiovascular Medicine, Department of Medicine, University of California, School of Medicine, 95616, Davis, California, (USA)

  2. D. T. Mason (Recipient of Research Career Development Award KO4 HL00466-01)

    Present address: Division of Cardiology, University of California, Medical School San Francisco, 94122, San Francisco, California

Authors and Affiliations

  1. Section of Cardiovascular Medicine, Department of Medicine, University of California, School of Medicine, 95616, Davis, California, (USA)

    D. Stewart & D. T. Mason (Recipient of Research Career Development Award KO4 HL00466-01)

Authors
  1. D. Stewart
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  2. D. T. Mason
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  3. J. Wikman-Coffelt Ph.D.
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Additional information

With 3 figures and 3 tables

This study was supported by NIH-ROI-HL-21820 from the National Institutes of Health, Bethesda, Maryland.

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Stewart, D., Mason, D.T. & Wikman-Coffelt, J. Changes in cAMP concentrations during chronic cardiac hypertrophy. Basic Res Cardiol 73, 648–655 (1978). https://doi.org/10.1007/BF01906802

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  • DOI: https://doi.org/10.1007/BF01906802

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