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Hepatic blood flow during rapid intravenous glucose tolerance test

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Research in Experimental Medicine

Summary

Twenty-nine dogs anesthetized with Na-pentobarbital were laparatomized and liver blood flow was measured by133Xe clearance method. Fifteen dogs of the experimental group were subjected to rapid i.v. glucose tolerance test whereas 14 animals of the control group were treated identically except for infusion of glucose. It was found that the arterial and the portal venous blood glucose rose significantly during the glucose tolerance test. Liver blood flow in the experimental group was 123.8 ml/100g L/min after operative procedures. It reached 171.9 ml/100g L/min at 10 min after infusion of glucose (P<0.01). At 20, 30, and 40 min of the test it was 145.4 (P<0.05), 143.4 (P<0.01), 135.1 (P>0.05) mg/100g L/min, respectively. Liver blood flow did not change significantly during the observation period in the control series. It is concluded that glucose loading may produce some metabolic effects secondary to rising liver blood flow in addition to changes induced by its rising concentration.

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Authors and Affiliations

  1. Medical and Surgical Research Center, Hacettepe University, Medical School, Ankara, Turkey

    Naci M. Bor, Muhlise Alvur, Meral Ercan & Coskun F. Bekdik

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  1. Naci M. Bor
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  2. Muhlise Alvur
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  3. Meral Ercan
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  4. Coskun F. Bekdik
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Additional information

Supported in part by Grants Nos. 264 and 315 of the Turkish Scientific Technical Research Council

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Bor, N.M., Alvur, M., Ercan, M. et al. Hepatic blood flow during rapid intravenous glucose tolerance test. Res. Exp. Med. 177, 159–165 (1980). https://doi.org/10.1007/BF01851844

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  • DOI: https://doi.org/10.1007/BF01851844

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