Summary
The Sapirstein method was used to study the circulatory conditions of hypophysectomized rats treated with oestrogen and with vasopressin. It was found that in rats hypophysectomized for several weeks there are decreases in the blood pressure, cardiac output, renal fraction of the cardiac output and the renal blood flow. 1 hr after vasopressin injection following a 10-day oestrone pretreatment, the renal fraction of the cardiac output and the renal blood flow decreases significantly compared to the hypophysectomized untreated group, and the renal vascular resistance increases to a considerable extent. The vasoconstriction can also be detected in the kidneys of oestrone-pretreated hypophysectomized animals, following the administration of vasopressin.
The protective effect of hypophysectomy against renal cortical necrosis induced by hormone treatment is therefore not exerted by means of the inhibition of the renal vasospasm. It may be presumed that after the hypophysectomy the O2 demand of the kidneys decreases and so the kidneys better endure the O2 deficiency caused by the renal vasospasm.
Similar content being viewed by others
References
Astarabadi, T.: The effect of hypophysectomy, adrenalectomy and ACTH administration on compensatory renal hypertrophy in rats. Quart. J. exp. Physiol.48, 80–84 (1963a)
Astarabadi, T.: The effect of growth and lactogenic hormones on renal compensatory hypertrophy in hypophysectomized rats. Quart. J. exp. Physiol.48, 85–92 (1963b)
Berlin, N. I., Vand Dyke, D. C., Siri, W. E., Williams, C. P.: The effect of hypophysectomy on the total circulating red cell volume of the rat. Endocrinology47, 429–435 (1950)
Beznák, M.: Behaviour of weight of heart and blood pressure of albino rats under different conditions. J. Physiol. (Lond.)124, 44–63 (1954a)
Beznák, M.: Restoration of cardiac hypertrophy and blood pressure in hypophysectomized rats by large doses of lyophilized anterior pituitary and growth hormone. J. Physiol. (Lond.)124, 64–74 (1954b)
Beznák, M.: Effect of adrenocortical hormones alone and in combination with growth hormone on cardiac hypertrophy and blood pressure of hypophysectomized rats. J. Physiol. (Lond.)124, 75–83 (1954c)
Beznák, M.: The effect of different degrees of subdiaphragmatic aortic constriction on heart weight and blood pressure of normal and hypophysectomized rats. Canad. J. Biochem.33, 985–994 (1955)
Beznák, M.: Hemodynamic changes following aortic constriction in normal and in hypophysectomized rats. Canad. J. Biochem.34, 791–798 (1956)
Beznák, M.: Hemodynamic changes in hypophysectomized rats. Circulat. Res.7, 907–916 (1959)
Beznák, M.: The role of anterior pituitary hormones in controlling size, work and strength of the heart. J. Physiol. (Lond.)150, 251–265 (1960)
Beznák, M.: Effect of growth hormone and thyroxin on cardiovascular system of hypophysectomized rats. Amer. J. Physiol.204, 279–283 (1963a)
Beznák, M.: Cardiovascular effects of thyroxine treatment in hypophysectomized rats. Circulat. Res.12, 333–340 (1963b)
Bojs, G., Falkheden, T., Sjögren, B.: Studies on glomerular filtration rate and renal plasma flow in pituitary insufficiency in man including measurements of the renal extraction of para-aminohippuric acid. Acta endocr.37, 616–621 (1961)
Bojs, G., Falkheden, T., Sjögren, B., Varnauskas, E.: Haemodynamic studies in man before and after hypophysectomy. Acta endocr.39, 308–322 (1962)
Boss, W. R., Osborn, C. M., Renzi, A. A.: Effects of adrenal cortical extract on renal function in hypophysectomized rats. Endocrinology51, 66–74 (1952)
Byrom, F. B.: Effect of oestrogenic and other sex hormones on the response of the rat to vasopressin. Lancet1938 I, 129–131
Byrom, F. B., Pratt, O. E.: Oxytocin and renal cortical necrosis. Lancet1959 I, 753–754
Falkheden, T.: Renal function following hypophysectomy in man. Acta endocr.42, 571–590 (1963)
Falkheden, T., Sjören, B., Westling, H.: Studies on the blood volume following hypophysectomy in man. Acta endocr.42, 552–563 (1963)
Goldman, H.: Effect of acute stress on the pituitary gland. Endocrine gland blood flow. Endocrinology72, 588–591 (1963)
Goldman, H., Sapirstein, L. A.: Determination of blood flow to the rat pituitary gland. Amer. J. Physiol.194, 433–435 (1958)
Hajdu, I., Beznák, M.: Die Rolle der Hypophyse bei der Regulierung von Arbeitsvermögen und Masse des Herzens. Schweiz. med. Wschr.75, 665–670 (1945)
Hamilton, W. F., Moore, J. W., Kinsman, J. M., Spurling, R. G.: Studies on circulation; further analysis of the injection method and of changes in hemodynamics under physiological and pathological conditions. Amer. J. Physiol.99, 534–551 (1932)
Howell, D. S., Davis, J. O., Laqueur, G. L.: Effect of hypophysectomy on electrolyte excretion in dogs with ascites produced by thoracic inferior vena cava constriction. Circulat. Res.3, 264–273 (1955)
Kocsis, J., László, F. A., Csernay, L., Kovács, K.: Renal circulation in rats treated with hexadimethrine bromide. Urol. int. (Basel)26, 269–276 (1971)
Kovács, K.: Die Rolle des Hypothalamus-Adenohypophysensystem im Wasserhaushalt. Studia Medica Szegediensia, Szeged (Orvostudományi Egyetem) VI. 237 (1963)
Kovács, K., Csernay, L., Dávid, M. A., László, F. A., Biró, A.: Haemodynamical changes in cortisone-treated hypophysectomized rats. Acta med. hung.21, 141–148 (1965a)
Kovács, K., Dávid, M. A.: Hormonokkal elöidézett vesekéregnekrosis. Orv. Hetil.104, 1405–1407 (1963)
Kovács, K., Dávid, M. A., László, F. A.: Effect of hypophysectomy on the development of renal cortical necrosis induced by posterior pituitary extract in oestrone pretreated rats. Brit. J. exp. Path.45, 415–418 (1964)
Kovács, K., László, F. A., Sövényi, E., Kocsis, J.: Angio-renographic studies in living rats during the development of renal cortical necrosis. Brit. J. Radiol.38, 148–151 (1965b)
László, F. A., Mónus, Z.: The effects of oestrogen, ACTH and cortisone administration and hypophysectomy on histological changes induced by unilateral renal pedicle clamping. Brit. J. exp. Path.54, 306–311 (1973)
László, F. A., Soós, I., Csernay, L.: The effects of hypophysectomy and administration of oestrogen or ACTH on renal oxygen consumption in rats. In preparation (1974)
McQueen-Williams, M., Thompson, K. W.: Effect of ablation of hypophysis upon weight of kidney of rat. Yale J. Biol. Med.12, 531–541 (1940)
Roger, M. M.: Circulatory changes in dehydration. Acta med. hung.21, 35–41 (1965)
Sapirstein, L. A.: Regional blood flow by fractional distribution of indicators. Amer. J. Physiol.193, 161–168 (1958)
Takács, L.: Effect of adrenaline and noradrenaline on cardiac output and regional blood flow in the rat. Acta physiol. hung.27, 205–212 (1965)
Takács, L., Kukucska, J.: Effect of chronic anaemia on cardiac output and organ blood flow in the rat. Acta med. hung.20, 71–77 (1964)
White, H. L., Heinbecker, P., Rolf, D.: Some endocrine influences on renal function and cardiac output. Amer. J. Physiol.149, 404–417 (1947)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
László, F.A., Csernay, L. & Kocsis, J. Effect of hypophysectomy on haemodynamic changes induced by administration of oestrone + vasopressin. Res. Exp. Med. 163, 219–227 (1974). https://doi.org/10.1007/BF01851669
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01851669